Tissue section imaging plays a key role in pathology and disease research. By slicing tissue samples into thin sections and applying specific staining or labeling methods, researchers are able to observe and analyze cellular and molecular structures in tissues. In addition, tissue section imaging can be used to study the expression of specific biological targets and to determine the expression levels and spatial distribution of these biological targets in different tissue types and pathological states. Tissue section imaging services can help researchers gain insights into the pathological changes of diseases, evaluate therapeutic drug co-localization and develop new therapeutic approaches. https://www.bioimagingtech...

Ceramic materials have high hardness, low density, excellent chemical stability, corrosion resistance, low coefficient of thermal expansion, and are poor conductors of electricity and heat. Ceramic 3D printing is an emerging field in recent years, and has been widely used in the production of tableware, artwork and cultural. The traditional ceramic processing industry is time-consuming and costly. Combining 3D printing technology with ceramic materials can greatly shorten the production cycle and cost, and is gradually applied in many fields. 3D printed ceramics can not only obtain parts with complex shapes, but also overcome many challenges brought on by traditional ceramic processes. https://www.3dmicroflu.com...

Post-translational modifications (PTMs) are important components in signaling transductions, which affect the activity of proteins in signaling pathways. Phosphorylation is the most common PTM. The other PTMs include acetylation, methylation, glycosylation, lipidation, nitrosylation and ubiquitination.

In signaling pathways, proteins exist in two states: activated and inactivated, which are generally under the regulation PTMs. PTMs mediate signaling transductions during cell proliferation and differentiation, immune response, metabolism, apoptosis, etc. Any dysregulation of PTMs in the cells leads to different levels of functional failures. Thus, learning how protein PTMs modulate signaling pathways are of great importance.

CD BioSciences offers a complete portfolio of solutions for resolve PTM-related issues including PTM profiling, substrate and enzyme identification and inhibitor/activator screening. https://www.cd-biosciences...

Gelatin is extracted from collagen in connective tissues such as animal skin, bone, and muscle membranes. As a biocompatible polymer, it has been used as a delivery vehicle for releasing active biomolecules and generating scaffolds for tissue engineering applications. https://www.3dmicroflu.com...

Bacteria are prokaryotic microorganisms that widely exist in nature and have the characteristics of small size, simple structure and strong environmental adaptability. Bacteria have many impacts on people's daily life and production. Various genetically engineered bacteria can be used in food production, pharmaceutical production and environmental purification. In addition, bacteria can cause food nutrient loss, flavor changes, and shelf-life spoilage. Most bacteria will not cause harm to people, but the existence of some serious pathogenic bacteria will threaten human life and health. Therefore, imaging analysis of bacterial structural and morphological changes and their growth status is of great significance for the treatment of diseases caused by bacterial infection. https://www.bioimagingtech...

A virus is a specialized organism without a cellular structure, consisting of a protein coat and genetic material inside. Since viruses are acellular, they cannot achieve numerical growth through cell division. They use the metabolic tools in the host cell to synthesize copies of themselves and complete viral assembly. Viruses are everywhere, and many human diseases are caused by viral infections. Virus imaging analysis is a tool to study the structure and infection mechanism of virus. It is very important for the development of therapeutic methods for diseases caused by virus infection. https://www.bioimagingtech...

Autophagy is an orderly circulatory system within a cell that can degrade unnecessary cytoplasmic proteins and damaged organelles. It is a dynamic autophagy process that exists in all eukaryotic cells. Autophagy is important for cells to resist intracellular and extracellular stress and maintain metabolic homeostasis. It is involved in many physiological events, including cell renewal, cell growth, immunity and aging. Recent evidence indicates that changes in autophagy often occur in many human diseases, such as neurodegenerative diseases, cancer, and cardiomyopathy. Therefore, finding new drugs that target the autophagy pathway is essential for the treatment of human diseases. https://www.bioimagingtech...

As a trusted 3D bioprinting biotech company, CD BioSciences' experienced team of experts can offer you various types of in vitro model building services based on the high-resolution 3Dmicroflu™ technology platform covering all aspects of life science research. Here, the advantages and applications of 3Dmicroflu™ technology platform in the construction of diabetes 's disease micro models are demonstrated in the following section. https://www.3dmicroflu.com...

Cell signaling pathways allow cells to communicate with their environment. There are three stages in a cell signaling event: reception, transduction, response. Different signaling pathways control different cellular processes. But all signaling pathways share a common goal, that is, to generate appropriate cellular responses to accommodate environmental changes.

Studying cellular responses is to understand the ultimate outcome of a signaling transduction event. CD BioSciences offers a complete portfolio of solutions for studying cellular responses to signaling, covering gene expression, cell metabolism, cell growth and other cell behaviors. https://www.cd-biosciences...

Post-translational modifications (PTMs) are important components in signaling transductions, which affect the activity of proteins in signaling pathways. Phosphorylation is the most common PTM. The other PTMs include acetylation, methylation, glycosylation, lipidation, nitrosylation and ubiquitination.

In signaling pathways, proteins exist in two states: activated and inactivated, which are generally under the regulation PTMs. PTMs mediate signaling transductions during cell proliferation and differentiation, immune response, metabolism, apoptosis, etc. Any dysregulation of PTMs in the cells leads to different levels of functional failures. Thus, learning how protein PTMs modulate signaling pathways are of great importance. https://www.cd-biosciences...

The key to understanding the mechanism of a signaling pathway is to identify and characterize the TFs functioning downstream the signaling pathway. CD BioSciences offers a complete portfolio of solutions covering every aspect of TF studies, including binding motif analysis, domain mapping, and interacting protein identification. https://www.cd-biosciences...

Drug discovery is an interdisciplinary field, focusing on the identification and preclinical testing of candidate drugs in vitro, ex vitro and in vivo. The research and development of new drugs is divided into two stages: research and development. These two stages occur successively and are interrelated. The mark that distinguishes the two stages is the determination of candidate drugs, that is, the research stage is before the determination of candidate drugs, and the work after the determination is the development stage. In recent years, imaging technology has been used in the process of drug research and development, which has greatly promoted the development of the medical field. https://www.bioimagingtech...

As a trusted 3D bioprinting biotech company, CD BioSciences' experienced team of experts can offer you various types of in vitro model building services based on the high-resolution 3Dmicroflu™ technology platform covering all aspects of life science research. Here, the advantages and applications of 3Dmicroflu™ technology platform in the construction of Parkinson's Disease micro models are demonstrated in the following section. https://www.3dmicroflu.com...

CD BioSciences offers a variety of antibody array testing services covering a wide range of signaling pathways. With our ELISA based platform for high-throughput protein profiling in cells, tissues, serum, or even culture media, you are freed from lousy work like conventional Western Blots or traditional ELISA. https://www.cd-biosciences...

An antibody array is a form of protein microarray which is a high-throughput technology for protein profiling. In this technology, a collection of antibodies is spotted and fixed on a solid surface such as glass, plastic, membrane, or silicon chip, and the interaction between the antibody and its target antigen is detected. It can be used to detect the levels of protein expression or post-translational modification (PTM). https://www.cd-biosciences...

Signaling pathways regulate cellular processes, such as apoptosis, inflammation, metabolism and angiogenesis. Dysregulations of signaling-transduction pathways lead to malfunction of those processes and result in pathological or disease states.

To have a better understanding of the regulation of signaling pathways and find potential drugs or treatments for diseases, CD BioSciences offers well-established cell-based reporter assays to evaluate the impact of therapeutics or gene manipulations in signaling pathways. https://www.cd-biosciences...

Hematoxylin-Eosin (H&E) staining has been used for more than a century and is still essential for identifying various tissue types and the morphological changes that form the basis of modern cancer diagnosis. For routine diagnosis, pathologists prefer H&E when observing the details of cell and tissue structure. H&E can display a wide range of cytoplasm, nucleus and extracellular matrix characteristics, for this reason, almost all teaching texts use H&E images. Hematoxylin has a dark blue-violet color and dyes nucleic acids through complex reactions. Eosin is pink and non-specifically stains proteins. In a typical tissue, the nucleus is blue, while the cytoplasm and extracellular matrix are pink to varying degrees. Well-fixed cells show considerable intranuclear detail. https://www.bioimagingtech...

Polycarbonate (PC) is a strong thermoplastic resin with many advantages, such as good mechanical properties, thermal stability, and light transmission. Based on these properties, PC bioinks are used differently from other bioinks and are mainly used for printing in 3D cell and tissue culture devices to facilitate optical observation of cell growth. https://www.3dmicroflu.com...

The performance of retailers is closely related to factors such as sales, customer flows, market trends, etc. In this case, statistical techniques help with analysis, focusing on the abovementioned factors to improve performance. According to statistical analysis, retailers can easily make decisions about pricing, inventory management, and even marketing campaigns, which suggests the importance of statistical analysis for the retail industry. https://www.highrun-ds.com...

A protein phosphatase (PP) is an enzyme catalyzing the removal/hydrolysis of phosphate groups from phosphorylated amino acid residues (Ser, Thr and Tyr) of proteins. The process is termed dephosphorylation. There are approximately 200 phosphatases in the human proteome. Since many kinases are oncogenes, phosphatases, counterbalancing the activity of kinases, are likely to act as tumor suppressors, such as PTEN. They are essential for brain function such as learning and memory. Dysregulation of PPs is associated with disorders inducing autoimmune diseases, cognitive ageing and neurodegeneration, as well as cancer, diabetes and obesity. https://www.cd-biosciences...

Ubiquitination (ubiquitinylation) is a post-translational modification (PTM) process, where a ubiquitin is added to a lysine/cysteine/ serine/threonine of a substrate protein via the C-terminal glycine of ubiquitin. It is essential for balancing numerous physiological processes. Through altering proteins' degradation, cellular location, activity, and interactions with other molecules, ubiquitination regulates protein functions in relevant signaling pathways. https://www.cd-biosciences...

Ubiquitination (ubiquitinylation) is a post-translational modification (PTM) process, where a ubiquitin is added to a lysine/cysteine/ serine/threonine of a substrate protein via the C-terminal glycine of ubiquitin. It is essential for balancing numerous physiological processes. Through altering proteins' degradation, cellular location, activity, and interactions with other molecules, ubiquitination regulates protein functions in relevant signaling pathways. https://www.cd-biosciences...

Cells constantly communicate with each other and with the surrounding environment. Cell signaling or cell-cell communication governs the basic activities of cells, including proliferation, metabolism, and stress response. Understanding how cell signaling is perceived, processed and responded requires the study of the mechanisms of signaling pathways, i.e., which protein is functionally involved in which pathway and how it functions. https://www.cd-biosciences...

Signaling pathways regulate cellular processes, such as apoptosis, inflammation, metabolism and angiogenesis. Dysregulations of signaling-transduction pathways lead to malfunction of those processes and result in pathological or disease states.

To have a better understanding of the regulation of signaling pathways and find potential drugs or treatments for diseases, CD BioSciences offers well-established cell-based reporter assays to evaluate the impact of therapeutics or gene manipulations in signaling pathways. https://www.cd-biosciences...

CD BioSciences is a biotechnology company with a high-resolution 3D bioprinting technology platform dedicated to providing bioink products and its customization services. CD BioSciences can offer the following hyaluronic acid-based 3D bioprinting bioinks for you to choose from. https://www.3dmicroflu.com...

Nanoparticles are becoming multifunctional tools in biomedical applications, especially in the field of biomedical imaging. Nanoparticles can be used to diagnose, monitor physical and pathological processes, treat and control biological systems. Nanoparticles are usually less than 100nm in size, and they can be made of materials with different chemical properties, the most common being metals, metal oxides, silicates, polymers, carbon, lipids, and biomolecules. Nanomaterials have diverse chemical surface properties, unique magnetic properties, and adjustable absorption and emission properties. They can be designed in different sizes, shapes, chemical surface properties and hollow, porous or solid structures. https://www.bioimagingtech...

Cancer describes the disease with uncontrolled cell growth. It's one of the most common causes of death in the United States. The financial costs of cancer are estimated to be over $150 billion per year nationally. Thus, the research of cancer has always been popular, aiming at the development of safe and effective methods to prevent, detect, diagnose, treat and ultimately cure the disease.

As a trusted CRO, CD BioSciences provides a comprehensive panel of solutions covering all aspects of life science research, including cancer. https://www.cd-biosciences...

Cell death is a fundamental biological process, which has been extensively explored in the past several decades. Active cell death (apoptosis, necroptosis, pyroptosis ferroptosis, alkaliptosis and oxeiptosis) are tightly regulated by signaling pathways.

Since cell death is closely linked to diseases, the in-depth characterization of cell death events may uncover novel therapeutic targets. As a trusted CRO, CD BioSciences provides a comprehensive panel of solutions covering all aspects of life science research, including cell death.

https://www.cd-biosciences...