At a meeting on plasma physics in Saltzberg in 1961, the Soviet delegation presented considerable data showing the instability, while the US teams continued to show none. An offhand question by Lev Artsimovich settled the matter; when he asked if the charts being produced from the instruments in the US machines were adjusted for a well-known delay in the output of the detectors being used, it suddenly became clear that the apparent 1 ms stability was, in fact, a 1 ms delay in the measurements. Post was forced to conclude "we now do not have a single experimental fact indicating long and stable confinement of plasma with hot ions within a simple magnetic mirror geometry."

An early bottleneck in the rapid isolation of new antibody fragment binders using in vitro library approaches is the inertia encountered in acquiring and preparing soluble antigen fragments. In this report, we describe a simple, yet powerful strategy that exploits the properties of the SpyCatcher/SpyTag (SpyC/SpyT) covalent interaction to improve substantially the speed and efficiency in obtaining functional antibody clones of interest.