Experienced in macrophage development and with a dedicated commitment to the scientific community, Creative Biolabs has perfected our technical pipelines in the identification of M1 and M2 macrophages. We are happy to share our knowledge and passion in this field to facilitate our clients' research and project development. Learn more, https://macrophage.creativ...

By applying our state-of-the-art Macrophage Therapeutics Development Platform as well as industry-leading expertise, Creative Biolabs provides overall solutions for macrophage reprogramming, focusing on innovative research. Our multidisciplinary scientists will work together closely to address the scientific and technical challenges in macrophage reprogramming. Learn more, https://macrophage.creativ...

Macrophages are able to initiate a particular type of inflammatory response via the release of a certain pattern of cytokines. They play a major role as immunoregulatory cells. Creative Biolabs has built a highly experienced team of scientists and quality staff that have a long history in macrophage isolation and culture. Learn more, https://macrophage.creativ...

As a type of functionally diversified immune cell widely spread throughout the whole body, macrophages play critical roles in the regulation of homeostasis, inflammation, and antitumor immunity in a specific manner. Macrophages are easily transformed into inflammatory (M1) and can also demonstrate effective phagocytosis. The M1 profile is classically associated with the control of bacterial infections. Creative Biolabs offers highly customized assays to induce M1 macrophages and characterize their polarization states. Learn more, https://macrophage.creativ...

Creative Biolabs is dedicated to providing a full range of antibody and peptide discovery services from vector construction to antibody production and antibody efficacy assessment, helping clients discover and develop highly effective and specific anti-infective hits. Learn more, https://www.creative-biola...

Creative Biolabs is actively supporting and assisting clients in exploring and developing the enormous potential of interfering nucleic acid drugs in the treatment of infectious diseases. Learn more, https://www.creative-biola...

The discovery of effective targets to restrict the growth and spread of pathogens is critical to infectious illness treatment. Creative Biolabs provides high-throughput proteomics analysis services that can identify disease-associated proteins, thus helping to discover possible targets for intervention in infections. Learn more, https://www.creative-biola...

Creative Biolabs is dedicated to providing comprehensive solutions for infectious disease research with scalable genomics approaches. Through comprehensive genomic analysis, researchers are able to identify and discover possible targets, monitor host-pathogen interactions, study pathogen evolution and predict the occurrence of drug-resistant genotypes. Learn more, https://www.creative-biola...

https://www.creative-biola... developing various biomarkers or targets to better diagnose or treat non-alcoholic steatohepatitis (NASH), preclinical testing tools are needed for compound screening and mechanical studies. As part of our portfolio of NASH-related services, Creative Biolabs offers customized in vitro-engineered liver model services to study drugs or biomarkers for NASH treatment. Learn more,

Neutralizing Antibodies and Antimicrobial Peptides Targeting S Protein Neutralizing antibodies are induced by antigens to protect cells from pathogen infection. Most neutralizing antibodies function at the earliest steps of viral infection through blocking interaction of the virus with cellular receptors and prevent entry into host cells. It has been reported that RBD of S protein efficiently elicits neutralizing antibodies against MERS-CoV by blocking viral entry at the binding step. Learn more, https://www.creative-biola...

Andes Virus (ANDV), a type of orthohantavirus, belongs to the family Hantaviridae which consists of 5 genera: bunyavirus, phlebovirus, nairovirus, tospovirus, and hantavirus. This virus was first found in rodent at Andes mountains of Chile and Argentina. ANDV infection is a leading cause of hantavirus cardiopulmonary syndrome (HCPS), hantavirus pulmonary syndrome (HPS), and hemorrhagic fever with renal syndrome/failure (HFRS). ANDV maintains persistent apathogenic infections in rodents and is easily transmitted to humans mainly through inhalation of aerosolized rodent excreta or rodent bites, leading to the occurrence of ANDV-infected diseases. Besides, ANDV is the only hantavirus that is capable of person-to-person transmission. Learn more, https://www.creative-biola...

LAG-3 inhibitor plays an important role in T cell proliferation and activation as a negative regulator of these processes. Along with other inhibitory receptors, LAG-3 helps to keep cytotoxic CD8+ T cells in an exhausted state during highly inflammatory environments such as a chronic viral infection. LAG-3 has also been implicated in memory T cell expansion, Treg function, and the activation and maturation of dendritic cells. Learn more, https://immune-checkpoint....

Normally, checkpoint inhibitors have to be tested for immuno-modulatory activities using functional assays. Following stimulation, execution of functional assays is performed, such as T cell proliferation assay, cytokine production assay, and T cell cytotoxicity assay. These functional assays are offered in a high throughput method so multiple molecules and conditions can be incorporated. Tailored immune checkpoint assay is also available. In that case, a unique reporter cell line could also be used to determine if your inhibitor can restore immune cell function. Learn more, https://immune-checkpoint....

With our world-leading technology platforms and professional experts at antibody development, Creative Biolabs has perfected our technical pipelines in immune checkpoint antibody development. Our comprehensive service portfolio includes polyclonal antibody discovery and development, monoclonal antibody (mAb) discovery and development, antibody fragment discovery and development, antibody characterization, antibody engineering and optimization, antibody production, and manufacture. We will share our knowledge and passion for immune checkpoint antibody development to facilitate our customers' research and project development. Learn more, https://immune-checkpoint....

Numerous cell lines, including Vero and HeLa cells, can isolate orthopox viruses. The method of identification has been subcultured to chick chorioallantoic membrane cells, although more recent techniques, including NAA, are being employed more and more for end-point assessment. Creative Biolabs has been keeping a close eye on the development of the epidemic situation. The cell culture scientists at Creative Biolabs are focused on optimizing all characteristics unique to your cell lines in order to manufacture cell lines effectively and in accordance with your specifications. Learn more about monkeypox cell lines, https://monkeypox.creative...

With years of experience, Creative Biolabs can offer an extensive range of recombinant proteins and peptides including orthopoxviruses family, parapoxviruses family, molluscipoxviruses family, yatapoxviruses family, capripoxviruses family, suipoxviruses family, leporipoxviruses family and avipoxviruses family. Creative Biolabs is committed to providing highly customized comprehensive solutions with the best quality to advance your projects. Learn more, https://monkeypox.creative...

With years of experience, Creative Biolabs developed a comprehensive list of Monkeypox related products to support the development of antibody and other therapeutics, including recombinant proteins and peptides, antibodies, plasmids, PCR primers and probes, cell lines, inhibitors, virus like particles and pseudoviruses and detection kits. Learn more, https://monkeypox.creative...

Creative Biolabs is dedicated to providing several viable and cost-effective methods for pluripotent stem cells (iPSC) reprogramming. We employ advanced iPSC reprogramming factor delivery strategy by virus, iPSC reprogramming factor delivery by episomal vectors, as well as other iPSC reprogramming methods (mRNA, protein) to help you obtaining the desired iPSC. Learn more, https://www.creative-biola...

Creative Biolabs have the ability to provide stem cell-based therapeutics development. Since stem cells are vital to the development, growth, maintenance, and repair of brains, bones, muscles, nerves, blood, skin, and other organs, we provided disease-specific stem cells therapy services, iPSC-derived cells therapy services. Also, to fit the rapid growth of stem cell therapy around the world, our scientists are using stem cells to develop customized disease modeling and to facilitated new drugs discovery for clients worldwide. Learn more, https://www.creative-biola...

Complement component C9 is a multidomain protein containing an N-terminal type 1 TSP domain, an LDL receptor class A repeat, many potential transmembrane regions, and a C-terminal EGF-like domain. Hydrophilic analysis of the sequence showed that the N-terminal half of C9 was mainly hydrophilic, while the C-terminal part was hydrophobic. Learn more, https://www.creative-biola...

C8 is a glycoprotein composed of three nonidentical subunits (C8α, C8β, and C8γ) that are encoded by three separate genes. C8α and C8β are members of the membrane attack complex (MAC) family of structurally related proteins. In contrast, C8γ is unrelated and is a member of the lipocalin family of widely distributed proteins that bind and transport small lipophilic ligands. Learn more, https://www.creative-biola...

The activation of three pathway results in the formation of the C5 convertase, which in turn cleaves C5 into C5a and C5b to initiate the formation of the terminal complement complex (TCC) at the targeted site sequentially together with C5b, C6, C7, C8 and C9, which is also called as the membrane attack complex (MAC). Assembly of the MAC on target cells results in the formation of transmembrane pores that can lead to the killing of the cells, which is the signature feature of complement. Learn more, https://www.creative-biola...

CAR-expressing T cells demonstrate impressive response rates hematological malignancies, but mediate limited anti-tumor efficacy in solid tumors. The T cell exhaustion-mediated dysfunction is an important barrier to progress, which raises the prospect that engineering exhaustion-resistant CAR-T cells could improve clinical outcomes. Learn more, https://www.creative-biola...

Although the T cells are difficult to modify using non-viral methods like lipid-based CAR-T plasmid transfection due to the high toxicity and low efficiency, the electroporation transfection and transposon based transfection systems are much more robust to complete the T-cell transfection. Learn more, https://www.creative-biola...

Based on the outstanding expertise and rich experience, Creative Biolabs has specially developed a comprehensive platform for CAR-T cell-based drug discovery. This platform enables us to offer GMP-level plasmid preparation, virus packaging, and T cell production services to help you discover new therapies. Learn more, https://www.creative-biola...

With the latest state-of-the-art technology and extensive experience, Creative Biolabs is the reliable choice for complement genetic testing, providing the highest standards in genetic testing with the latest technology, strictest quality control, and unprecedented service and reliability. https://www.creative-biola...

The complement system, also known as complement cascade, is an important part of the innate immune response consisting of a series of small proteins in the plasma or on cell surfaces. All the complement proteins interact and work together to “complement” or enhance the immune system to fight against pathogens. https://www.creative-biola...

Complement C1q-binding assay is mainly used for measuring the ability of antibody candidates binding to the complement C1q. For the assay, antibody samples developed by clients with different concentration gradients will be tested, and proper positive and negative controls will be included. https://www.creative-biola...

The success of anti-hapten antibody development for cadmium hinges on the meticulous design and synthesis of haptens. Researchers employ a combination of organic chemistry and immunological principles to create haptens that mimic the structure of cadmium ions. These synthetic haptens must be tailored to enhance immunogenicity while maintaining specificity for the target heavy metal. https://small-molecule-ant...

The development of anti-hapten polyclonal antibodies is a crucial aspect of the antibody development process. Polyclonal antibodies, derived from a diverse population of B cells, exhibit a broad spectrum of binding capabilities. https://small-molecule-ant...