The Mac
@TheMac
21 November, 02:15
Lesson of the day:
denucleate (third-person singular simple present denucleates, present participle denucleating, simple past and past participle denucleated)
To remove the nucleus
denucleate (third-person singular simple present denucleates, present participle denucleating, simple past and past participle denucleated)
To remove the nucleus
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The Mac
@TheMac
21 November, 02:24
In response The Mac to his Publication
defuse (third-person singular simple present defuses, present participle defusing, simple past and past participle defused)
(transitive) To remove the fuse from (a bomb, etc.).
(transitive, figuratively) To make less dangerous, tense, or hostile.
to defuse a hostage situation
(transitive) To remove the fuse from (a bomb, etc.).
(transitive, figuratively) To make less dangerous, tense, or hostile.
to defuse a hostage situation
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The Mac
@TheMac
21 November, 02:38
In response The Mac to his Publication
(computing, Internet) Any computer attached to a network.
(ecology) A cell or organism which harbors another organism or biological entity, usually a parasite.
Viruses depend on the host that they infect in order to be able to reproduce.
(evolution, genetics) An organism bearing certain genetic material.
The so-called junk DNA is known, so far, to provide no apparent benefit to its host.
(ecology) A cell or organism which harbors another organism or biological entity, usually a parasite.
Viruses depend on the host that they infect in order to be able to reproduce.
(evolution, genetics) An organism bearing certain genetic material.
The so-called junk DNA is known, so far, to provide no apparent benefit to its host.
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The Mac
@TheMac
21 November, 02:44
In response The Mac to his Publication
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The Mac
@TheMac
21 November, 02:46
In response The Mac to his Publication
(plural mediums, spiritualism) Someone who supposedly conveys information from the spirit world.
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The Mac
@TheMac
21 November, 02:48
In response The Mac to his Publication
From Middle English gost, gast, from Old English gāst (“breath, soul, spirit, ghost, being”), from Proto-West Germanic *gaist, from Proto-Germanic *gaistaz (“ghost, spirit”), from Proto-Indo-European *ǵʰéysd-os, from *ǵʰéysd- (“anger, agitation”). Cognate with Scots ghaist (“ghost”), Saterland Frisian Gäist (“spirit”), West Frisian geast (“spirit”), Dutch geest (“spirit, mind, ghost”), German Geist (“spirit, mind, intellect”), Swedish gast (“ghost”), Sanskrit हेड (héḍa, “anger, hatred”), Persian زشت (zešt, “ugly, hateful, disgusting”).
ghost (countable and uncountable, plural ghosts)
(uncommon or dated) The spirit; the soul of man.
The disembodied soul; the soul or spirit of a deceased person; a spirit appearing after death
Everyone believed that the ghost of an old lady haunted the crypt.
ghost (countable and uncountable, plural ghosts)
(uncommon or dated) The spirit; the soul of man.
The disembodied soul; the soul or spirit of a deceased person; a spirit appearing after death
Everyone believed that the ghost of an old lady haunted the crypt.
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The Mac
@TheMac
21 November, 02:51
In response The Mac to his Publication
(soul): essence, soul, spirit
(spirit appearing after death): apparition, bogey, haint, phantom, revenant, specter/spectre, spook, wraith.
(faint shadowy semblance): glimmer, glimmering, glimpse, hint, inkling, phantom, spark, suggestion.
(false image in an optical device):
(false image on a television screen): echo
(ghostwriter): ghostwriter
(unresponsive user):
(spirit appearing after death): apparition, bogey, haint, phantom, revenant, specter/spectre, spook, wraith.
(faint shadowy semblance): glimmer, glimmering, glimpse, hint, inkling, phantom, spark, suggestion.
(false image in an optical device):
(false image on a television screen): echo
(ghostwriter): ghostwriter
(unresponsive user):
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The Mac
@TheMac
21 November, 03:00
In response The Mac to his Publication
a small flash of light produced by a sudden disruptive electrical discharge through the air.
"there was a spark of light"
"there was a spark of light"
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The Mac
@TheMac
21 November, 03:03
In response The Mac to his Publication
spark1
/spɑːk/
verb
gerund or present participle: sparking
1.
emit sparks of fire or electricity.
"the ignition sparks as soon as the gas is turned on"
produce sparks at the point where an electric circuit is interrupted.
2.
ignite.
"the explosion sparked a fire"
provide the stimulus for (an event or process).
"the trial sparked a furious row"
give rise to
cause
lead to
set in motion
occasion
bring about
bring on
begin
start
initiate
precipitate
prompt
trigger (off)
set off
touch off
provoke
incite
stimulate
stir up
/spɑːk/
verb
gerund or present participle: sparking
1.
emit sparks of fire or electricity.
"the ignition sparks as soon as the gas is turned on"
produce sparks at the point where an electric circuit is interrupted.
2.
ignite.
"the explosion sparked a fire"
provide the stimulus for (an event or process).
"the trial sparked a furious row"
give rise to
cause
lead to
set in motion
occasion
bring about
bring on
begin
start
initiate
precipitate
prompt
trigger (off)
set off
touch off
provoke
incite
stimulate
stir up
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The Mac
@TheMac
21 November, 03:04
In response The Mac to his Publication
From Middle English stiren, sturien, from Old English styrian (“to be in motion, move, agitate, stir, disturb, trouble”), from Proto-Germanic *sturiz (“turmoil, noise, confusion”), related to Proto-West Germanic *staurijan (“to destroy, disturb”). Cognate with Old Norse styrr (“turmoil, noise, confusion”), German stören (“to disturb”), Dutch storen (“to disturb”).
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The Mac
@TheMac
21 November, 03:07
In response The Mac to his Publication
stir (third-person singular simple present stirs, present participle stirring, simple past and past participle stirred)
(transitive) To incite to action
Synonyms: arouse, instigate, prompt, excite; see also Thesaurus:incite
(transitive) To disturb the relative position of the particles of, a liquid of suchlike, by passing something through it
Synonym: agitate
She stirred the pudding with a spoon.
He stirred his coffee so the sugar wouldn't stay at the bottom.
(transitive) To agitate the content of (a container), by passing something through it.
Would you please stir this pot so that the chocolate doesn't burn?
(transitive) To incite to action
Synonyms: arouse, instigate, prompt, excite; see also Thesaurus:incite
(transitive) To disturb the relative position of the particles of, a liquid of suchlike, by passing something through it
Synonym: agitate
She stirred the pudding with a spoon.
He stirred his coffee so the sugar wouldn't stay at the bottom.
(transitive) To agitate the content of (a container), by passing something through it.
Would you please stir this pot so that the chocolate doesn't burn?
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The Mac
@TheMac
21 November, 03:08
In response The Mac to his Publication
(transitive) To bring into debate; to agitate; to moot.
(transitive, dated) To change the place of in any manner; to move.
(intransitive) To move; to change one’s position.
(intransitive) To be in motion; to be active or bustling; to exert or busy oneself.
(intransitive) To become the object of notice; to be on foot.
(intransitive, poetic) To rise, or be up and about, in the morning.
Synonyms: arise, get up, rouse; see also Thesaurus:wake
(transitive, dated) To change the place of in any manner; to move.
(intransitive) To move; to change one’s position.
(intransitive) To be in motion; to be active or bustling; to exert or busy oneself.
(intransitive) To become the object of notice; to be on foot.
(intransitive, poetic) To rise, or be up and about, in the morning.
Synonyms: arise, get up, rouse; see also Thesaurus:wake
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The Mac
@TheMac
21 November, 03:11
In response The Mac to his Publication
stir (countable and uncountable, plural stirs)
The act or result of stirring (moving around the particles of a liquid etc.)
Can you give the soup a little stir?
agitation; tumult; bustle; noise or various movements.
Public disturbance or commotion; tumultuous disorder; seditious uproar.
Agitation of thoughts; conflicting passions.
The act or result of stirring (moving around the particles of a liquid etc.)
Can you give the soup a little stir?
agitation; tumult; bustle; noise or various movements.
Public disturbance or commotion; tumultuous disorder; seditious uproar.
Agitation of thoughts; conflicting passions.
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The Mac
@TheMac
21 November, 03:13
In response The Mac to his Publication
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The Mac
@TheMac
21 November, 03:15
In response The Mac to his Publication
Sonication is the act of applying sound energy to agitate particles in a sample, for various purposes such as the extraction of multiple compounds from plants, microalgae and seaweeds. Ultrasonic frequencies are usually used, leading to the process also being known as ultrasonication or ultra-sonication.
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The Mac
@TheMac
21 November, 03:16
In response The Mac to his Publication
Project MKUltra was the code name of an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency.
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The Mac
@TheMac
21 November, 03:18
In response The Mac to his Publication
A noninvasive, low-intensity ultrasound method that targets nerve cells, or neurons, can alter brain function to influence decision-making.
New research shows how a brain area called the anterior cingulate cortex controls a type of reasoning known as counterfactual thinking.
New research shows how a brain area called the anterior cingulate cortex controls a type of reasoning known as counterfactual thinking.
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The Mac
@TheMac
21 November, 03:22
In response The Mac to his Publication
brainwave
/ˈbreɪnweɪv/
noun
1.
an electrical impulse in the brain.
"there were systematic changes in brainwaves with sleep"
2.
INFORMAL
a sudden clever idea.
"then he had a brainwave"
/ˈbreɪnweɪv/
noun
1.
an electrical impulse in the brain.
"there were systematic changes in brainwaves with sleep"
2.
INFORMAL
a sudden clever idea.
"then he had a brainwave"
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The Mac
@TheMac
21 November, 03:24
In response The Mac to his Publication
move back and forth," Old English wafian "to wave, fluctuate" (related to wæfre "wavering, restless, unstable"), from Proto-Germanic *wab- (source also of Old Norse vafra "to hover about," Middle High German. ... Related: Wobbled; wobbling. The noun is attested from 1690s.
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The Mac
@TheMac
21 November, 03:28
In response The Mac to his Publication
whoa
/wəʊ/
exclamation: whoa; exclamation: woah
1.
used to express surprise, interest, or alarm, or to command attention.
"whoa, that's huge!"
/wəʊ/
exclamation: whoa; exclamation: woah
1.
used to express surprise, interest, or alarm, or to command attention.
"whoa, that's huge!"
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The Mac
@TheMac
21 November, 03:30
In response The Mac to his Publication
wobbling (plural wobblings)
The motion of something that wobbles.
The motion of something that wobbles.
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The Mac
@TheMac
21 November, 03:33
In response The Mac to his Publication
bles f (plural blessen, diminutive blesje n)
blaze (light-coloured spot on a horse's face)
Noun
bles
(anatomy) belly; abdomen
Verb
bles
past tense of blåse
blaze (light-coloured spot on a horse's face)
Noun
bles
(anatomy) belly; abdomen
Verb
bles
past tense of blåse
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The Mac
@TheMac
21 November, 03:36
In response The Mac to his Publication
lase
/leɪz/
Origin
1960s: back-formation from laser, interpreted as an agent noun.
/leɪz/
Origin
1960s: back-formation from laser, interpreted as an agent noun.
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The Mac
@TheMac
21 November, 03:38
In response The Mac to his Publication
enucleation (n.)
from its cover or capsule," 1640s, noun of action from verb enucleate (1540s), from Latin enucleatus "pure, clean," past participle of enucleare "to lay open, explain in detail," literally "to remove the kernel from" (see ex- + nucleus).
from its cover or capsule," 1640s, noun of action from verb enucleate (1540s), from Latin enucleatus "pure, clean," past participle of enucleare "to lay open, explain in detail," literally "to remove the kernel from" (see ex- + nucleus).
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The Mac
@TheMac
21 November, 03:39
In response The Mac to his Publication
enucleate (third-person singular simple present enucleates, present participle enucleating, simple past and past participle enucleated)
(transitive, biology) To remove the nucleus from (a cell).
(transitive, medicine) To remove without cutting into it; especially, to remove or gouge out (an eyeball or tumor).
(archaic) To explain; to lay bare.
Derived terms
enucleation
(transitive, biology) To remove the nucleus from (a cell).
(transitive, medicine) To remove without cutting into it; especially, to remove or gouge out (an eyeball or tumor).
(archaic) To explain; to lay bare.
Derived terms
enucleation
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The Mac
@TheMac
21 November, 03:42
In response The Mac to his Publication
lesson
/ˈlɛs(ə)n/
ARCHAIC
gerund or present participle: lessoning
instruct or teach (someone).
/ˈlɛs(ə)n/
ARCHAIC
gerund or present participle: lessoning
instruct or teach (someone).
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The Mac
@TheMac
21 November, 03:45
In response The Mac to his Publication
lesser
Alternative form of laissier
Alternative form of laissier
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The Mac
@TheMac
21 November, 03:52
In response The Mac to his Publication
little
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The Mac
@TheMac
21 November, 03:52
In response The Mac to his Publication
Lit all
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The Mac
@TheMac
21 November, 03:52
In response The Mac to his Publication
The generation lasers are short pulse (from tens of nanoseconds to femtoseconds) and high peak power lasers. Common lasers used for ultrasound generation are solid state Q-Switched Nd:YAG and gas lasers (CO2 or Excimers). The physical principle is of thermal expansion (also called thermoelastic regime) or ablation. In the thermoelastic regime, the ultrasound is generated by the sudden thermal expansion due to the heating of a tiny surface of the material by the laser pulse. If the laser power is sufficient to heat the surface above the material boiling point, some material is evaporated (typically some nanometres) and ultrasound is generated by the recoil effect of the expanding material evaporated. In the ablation regime, a plasma is often formed above the material surface and its expansion can make a substantial contribution to the ultrasonic generation. consequently the emissivity patterns and modal content are different for the two different mechanisms.
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The Mac
@TheMac
21 November, 03:54
In response The Mac to his Publication
The frequency content of the generated ultrasound is partially determined by the frequency content of the laser pulses with shorter pulses giving higher frequencies. For very high frequency generation (up to 100sGHz) femtosecond lasers are used often in a pump-probe configuration with the detection system (see picosecond ultrasonics).
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The Mac
@TheMac
21 November, 03:55
In response The Mac to his Publication
Picosecond ultrasonics is a type of ultrasonics that uses ultra-high frequency ultrasound generated by ultrashort light pulses. It is a non-destructive technique in which picosecond acoustic pulses penetrate into thin films or nanostructures to reveal internal features such as film thickness as well as cracks, delaminations and voids. It can also be used to probe liquids. The technique is also referred to as picosecond laser ultrasonics or laser picosecond acoustics.
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The Mac
@TheMac
21 November, 03:57
In response The Mac to his Publication
pick (one's) moment
To thoughtfully and prudently decide the best moment to act.
To thoughtfully and prudently decide the best moment to act.
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The Mac
@TheMac
21 November, 03:58
In response The Mac to his Publication
The absorption of an incident optical pump pulse sets up a local thermal stress near the surface of the sample. This stress launches an elastic strain pulse that propagates into the sample. The exact depth for the stress generation depends, in particular, on the material involved and the optical pump wavelength. In metals and semiconductors, for example, ultrashort-timescale thermal and carrier diffusion tends to increase the depth that is initially heated within the first ~1 ps.
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The Mac
@TheMac
21 November, 04:00
In response The Mac to his Publication
Acoustic pulses are generated with a temporal duration approximately equal to the acoustic transit time across this initially heated depth, in general greater than the optical absorption depth. For example, the optical absorption depths in Al and GaAs are ~10 nm for blue light, but the electron diffusion depths are ~50 and 100 nm, respectively. The diffusion depth determines the spatial extent of the strain pulse in the through-thickness direction.
The main generation mechanism for metals is thermal expansion, whereas for semiconductors it is often the deformation potential mechanism. In piezoelectric materials the inverse piezoelectric effect, arising from the production of internal electric fields induced by charge separation, may dominate.
The main generation mechanism for metals is thermal expansion, whereas for semiconductors it is often the deformation potential mechanism. In piezoelectric materials the inverse piezoelectric effect, arising from the production of internal electric fields induced by charge separation, may dominate.
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The Mac
@TheMac
21 November, 04:01
In response The Mac to his Publication
Photoinduced charge separation is the process of an electron in an atom or molecule, being excited to a higher energy level by the absorption of a photon and then leaving the atom or molecule to a nearby electron acceptor.
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The Mac
@TheMac
21 November, 04:03
In response The Mac to his Publication
unacceptable
/ʌnəkˈsɛptəb(ə)l/
adjective
not satisfactory or allowable.
"unacceptable behaviour"
intolerable
insufferable
unsatisfactory
impermissible
inadmissible
inappropriate
unsuitable
undesirable
unreasonable
objectionable
insupportable
offensive
obnoxious
disagreeable
disgraceful
deplorable
terrible
distasteful
displeasing
improper
unseemly
beyond the pale
bad
poor
not on
a bit much
out of order
out
not quite the done thing
too much
a bit thick
a bit off
off
not cricket
over the fence
exceptionable
condemnable
/ʌnəkˈsɛptəb(ə)l/
adjective
not satisfactory or allowable.
"unacceptable behaviour"
intolerable
insufferable
unsatisfactory
impermissible
inadmissible
inappropriate
unsuitable
undesirable
unreasonable
objectionable
insupportable
offensive
obnoxious
disagreeable
disgraceful
deplorable
terrible
distasteful
displeasing
improper
unseemly
beyond the pale
bad
poor
not on
a bit much
out of order
out
not quite the done thing
too much
a bit thick
a bit off
off
not cricket
over the fence
exceptionable
condemnable
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The Mac
@TheMac
21 November, 04:05
In response The Mac to his Publication
condemnation
/ˌkɒndəmˈneɪʃn/
noun
1.
the expression of very strong disapproval; censure.
"there was strong international condemnation of the attack"
censure
criticism
castigation
stricture
denunciation
damnation
vilification
opprobrium
reproof
disapproval
disapprobation
flak
a bad press
reprobation
arraignment
excoriation
objurgation
/ˌkɒndəmˈneɪʃn/
noun
1.
the expression of very strong disapproval; censure.
"there was strong international condemnation of the attack"
censure
criticism
castigation
stricture
denunciation
damnation
vilification
opprobrium
reproof
disapproval
disapprobation
flak
a bad press
reprobation
arraignment
excoriation
objurgation
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The Mac
@TheMac
21 November, 04:06
In response The Mac to his Publication
the action of condemning someone to a punishment; sentencing.
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The Mac
@TheMac
21 November, 04:07
In response The Mac to his Publication
TO SENTENCING
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The Mac
@TheMac
21 November, 04:09
In response The Mac to his Publication
sensible
/ˈsɛnsɪb(ə)l/
adjective
1.
done or chosen in accordance with wisdom or prudence; likely to be of benefit.
practical
realistic
responsible
full of common sense
reasonable
rational
logical
sound
circumspect
balanced
sober
no-nonsense
pragmatic
level-headed
serious-minded
thoughtful
commonsensical
down-to-earth
wise
prudent
mature
judicious
sagacious
sharp
shrewd
far-sighted
intelligent
clever
/ˈsɛnsɪb(ə)l/
adjective
1.
done or chosen in accordance with wisdom or prudence; likely to be of benefit.
practical
realistic
responsible
full of common sense
reasonable
rational
logical
sound
circumspect
balanced
sober
no-nonsense
pragmatic
level-headed
serious-minded
thoughtful
commonsensical
down-to-earth
wise
prudent
mature
judicious
sagacious
sharp
shrewd
far-sighted
intelligent
clever
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The Mac
@TheMac
21 November, 04:10
In response The Mac to his Publication
late Middle English (also in the sense ‘perceptible by the senses’): from Old French, or from Latin sensibilis, from sensus (see sense).
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The Mac
@TheMac
21 November, 04:11
In response The Mac to his Publication
God bless.
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The Mac
@TheMac
21 November, 04:20
In response The Mac to his Publication
It is also possible to generate strain pulses whose shape does not vary on propagation. These so-called acoustic solitons have been demonstrated at low temperatures over propagation distances of a few millimeters. They result from a delicate balance between acoustic dispersion and nonlinear effects.
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John Qpublic
@Jamesbridgebuilder
21 November, 07:02
In response The Mac to his Publication
Would this be because heat causes expansion and therefore more friction? More friction less movement? No expansion=freedom?
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The Mac
@TheMac
22 November, 03:18
In response John Qpublic to his Publication
Thermal expansion is the tendency of matter to change its shape, area, volume, and density in response to a change in temperature, usually not including phase transitions.
Temperature is a monotonic function of the average molecular kinetic energy of a substance. When a substance is heated, molecules begin to vibrate and move more, usually creating more distance between themselves. Substances which contract with increasing temperature are unusual, and only occur within limited temperature ranges (see examples below). The relative expansion (also called strain) divided by the change in temperature is called the material's coefficient of linear thermal expansion and generally varies with temperature. As energy in particles increases, they start moving faster and faster weakening the intermolecular forces between them, therefore expanding the substance.
Temperature is a monotonic function of the average molecular kinetic energy of a substance. When a substance is heated, molecules begin to vibrate and move more, usually creating more distance between themselves. Substances which contract with increasing temperature are unusual, and only occur within limited temperature ranges (see examples below). The relative expansion (also called strain) divided by the change in temperature is called the material's coefficient of linear thermal expansion and generally varies with temperature. As energy in particles increases, they start moving faster and faster weakening the intermolecular forces between them, therefore expanding the substance.
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The Mac
@TheMac
22 November, 03:20
In response The Mac to his Publication
Local hyperthermia heats a very small area and is typically used for cancers near or on the skin or near natural openings in the body (e.g., the mouth). In some instances, the goal is to kill the tumor by heating it, without damaging anything else. The heat may be created with microwave, radiofrequency, ultrasound energy or using magnetic hyperthermia (also known as magnetic fluid hyperthermia)
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The Mac
@TheMac
22 November, 03:21
In response The Mac to his Publication
It should not be confused with ablation of small tumors, where higher temperatures (>55°C) are applied with an aim to kill the tumor cells
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The Mac
@TheMac
22 November, 03:23
In response The Mac to his Publication
Many scientists argue that even though viruses can use other cells to reproduce itself, viruses are still not considered alive under this category.
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The Mac
@TheMac
22 November, 03:24
In response The Mac to his Publication
So were they ever alive? Most biologists say no. Viruses are not made out of cells, they can't keep themselves in a stable state, they don't grow, and they can't make their own energy. Even though they definitely replicate and adapt to their environment, viruses are more like androids than real living organisms.
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The Mac
@TheMac
22 November, 03:29
In response The Mac to his Publication
Examples of liquid crystals can be found both in the natural world and in technological applications. Widespread liquid-crystal displays use liquid crystals. Lyotropic liquid-crystalline phases are abundant in living systems but can also be found in the mineral world. For example, many proteins and cell membranes are liquid crystals. Other well-known examples of liquid crystals are solutions of soap and various related detergents, as well as the tobacco mosaic virus, and some clays.
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The Mac
@TheMac
22 November, 03:36
In response The Mac to his Publication
The chemical composition of magnetite is Fe2+(Fe3+)2(O2-)4. This indicates that magnetite contains both ferrous (divalent) and ferric (trivalent) iron, suggesting crystallization in an environment containing intermediate levels of oxygen. The main details of its structure were established in 1915. It was one of the first crystal structures to be obtained using X-ray diffraction. The structure is inverse spinel, with O2− ions forming a face-centered cubic lattice and iron cations occupying interstitial sites. Half of the Fe3+ cations occupy tetrahedral sites while the other half, along with Fe2+ cations, occupy octahedral sites. The unit cell consists of 32 O2− ions and unit cell length is a = 0.839 nm.[
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The Mac
@TheMac
22 November, 03:37
In response The Mac to his Publication
Iron exists in two oxidation states: the ferrous cation (Fe2+) and ferric cation (Fe3+). Non-haem iron in food is mainly in the ferric state, which is the insoluble form of iron, and must be reduced to the ferrous cation for absorption
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The Mac
@TheMac
22 November, 03:38
In response The Mac to his Publication
When oxygen levels reached significant levels, iron reacted with oxygen, forming ferric oxide.
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The Mac
@TheMac
22 November, 03:40
In response The Mac to his Publication
Formula and structure: The iron (II) sulfate chemical formula is FeSO4. The molar mass is 151.91 g/mol. ... The molecule dehydrate es formed by one cation ferrous Fe2+ and one sulfate anion SO42-. Its chemical structure can be written as below, in the common representations used for organic molecules.
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The Mac
@TheMac
22 November, 03:42
In response The Mac to his Publication
Magnetic hyperthermia (MHT) utilizing heat generated by magnetic nanoparticles under alternating magnetic field (AMF) is an effective local tumor ablation method but can hardly treat metastatic tumors.
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The Mac
@TheMac
22 November, 03:44
In response The Mac to his Publication
We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability.
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The Mac
@TheMac
22 November, 03:44
In response The Mac to his Publication
We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed preferential growth of metastases on tissue surfaces and membranes such as the pleural and peritoneal layers, suggests a mechanism underlying the seed and soil hypothesis introduced by Stephen Paget in 1889, and yields realistic values for metastatic inefficiency. We propose a number of key experiments to test these concepts. The homeostatic pressure as introduced in this work could constitute a quantitative, experimentally accessible measure for the metastatic potential of early malignant growths.
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The Mac
@TheMac
22 November, 03:45
In response The Mac to his Publication
Self-assembly is the spontaneous organization of smaller subunits to form larger, well-organized patterns. For nanoparticles, this spontaneous assembly is a consequence of interactions between the particles aimed at achieving a thermodynamic equilibrium and reducing the system's free energy.
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The Mac
@TheMac
22 November, 03:46
In response The Mac to his Publication
Thermodynamic equilibrium is an axiomatic concept of thermodynamics. It is an internal state of a single thermodynamic system, or a relation between several thermodynamic systems connected by more or less permeable or impermeable walls. In thermodynamic equilibrium there are no net macroscopic flows of matter or of energy, either within a system or between systems.
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The Mac
@TheMac
22 November, 03:47
In response The Mac to his Publication
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The Mac
@TheMac
22 November, 03:48
In response The Mac to his Publication
Though not a widely named "law," it is an axiom of thermodynamics that there exist states of thermodynamic equilibrium. The second law of thermodynamics states that when a body of material starts from an equilibrium state, in which, portions of it are held at different states by more or less permeable or impermeable partitions, and a thermodynamic operation removes or makes the partitions more permeable and it is isolated, then it spontaneously reaches its own, new state of internal thermodynamic equilibrium, and this is accompanied by an increase in the sum of the entropies of the portions.
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The Mac
@TheMac
22 November, 03:51
In response The Mac to his Publication
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The Mac
@TheMac
22 November, 03:54
In response The Mac to his Publication
Both sensible and latent heats are observed in many processes of transfer of energy in nature. Latent heat is associated with the change of phase of atmospheric or ocean water, vaporization, condensation, freezing or melting, whereas sensible heat is energy transferred that is evident in change of the temperature of the atmosphere or ocean, or ice, without those phase changes, though it is associated with changes of pressure and volume.
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The Mac
@TheMac
22 November, 03:55
In response The Mac to his Publication
The original usage of the term, as introduced by Black, was applied to systems that were intentionally held at constant temperature. Such usage referred to latent heat of expansion and several other related latent heats. These latent heats are defined independently of the conceptual framework of thermodynamics.[3]
When a body is heated at constant temperature by thermal radiation in a microwave field for example, it may expand by an amount described by its latent heat with respect to volume or latent heat of expansion, or increase its pressure by an amount described by its latent heat with respect to pressure.[4]Latent heat is energy released or absorbed, by a body or a thermodynamic system, during a constant-temperature process. Two common forms of latent heat are latent heat of fusion (melting) and latent heat of vaporization (boiling). These names describe the direction of energy flow when changing from one phase to the next: from solid to liquid, and liquid to gas.
When a body is heated at constant temperature by thermal radiation in a microwave field for example, it may expand by an amount described by its latent heat with respect to volume or latent heat of expansion, or increase its pressure by an amount described by its latent heat with respect to pressure.[4]Latent heat is energy released or absorbed, by a body or a thermodynamic system, during a constant-temperature process. Two common forms of latent heat are latent heat of fusion (melting) and latent heat of vaporization (boiling). These names describe the direction of energy flow when changing from one phase to the next: from solid to liquid, and liquid to gas.
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The Mac
@TheMac
22 November, 04:04
In response The Mac to his Publication
"heated at constant temperature by thermal radiation in a microwave field for example"
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The Mac
@TheMac
22 November, 04:17
In response The Mac to his Publication
Microwaves use electricity for it energy source and transmits micrometer electromagnetic waves into the device. These waves then cause the water molecules in the food to move rapidly, producing heat.
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The Mac
@TheMac
22 November, 04:18
In response The Mac to his Publication
Electricity is related to charges, and both electrons and protons carry a charge. The amount of the charge is the same for each particle, but opposite in sign. Electrons carry a negative charge while protons carry positive charge. ... As a result, it is moving electrons that are primarily responsible for electricity.
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The Mac
@TheMac
22 November, 04:19
In response The Mac to his Publication
Piezoelectricity is the electric charge that accumulates in certain solid materials—such as crystals, certain ceramics, and biological matter such as bone, DNA, and various proteins—in response to applied mechanical stress. The word piezoelectricity means electricity resulting from pressure and latent heat.
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The Mac
@TheMac
22 November, 04:20
In response The Mac to his Publication
Latent heat is the energy absorbed by or released from a substance during a phase change from a gas to a liquid or a solid or vice versa. ... When these gas molecules condense into liquid drops, latent heat is released into the atmosphere which warms the air surrounding the molecule.
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The Mac
@TheMac
22 November, 04:21
In response The Mac to his Publication
A piezoelectric crystal is placed between two metal plates. ... At this point the material is in perfect balance and does not conduct an electric current. Mechanical pressure is then applied to the material by the metal plates, which forces the electric charges within the crystal out of balance.
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The Mac
@TheMac
22 November, 04:22
In response The Mac to his Publication
Acoustic attenuation is a measure of the energy loss of sound propagation in media. Most media have viscosity, and are therefore not ideal media. When sound propagates in such media, there is always thermal consumption of energy caused by viscosity.
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The Mac
@TheMac
22 November, 04:23
In response The Mac to his Publication
An attenuated vaccine (or a live attenuated vaccine, LAV) is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the virus (inactivated vaccine).
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The Mac
@TheMac
22 November, 04:25
In response The Mac to his Publication
Silica particles as a nanoparticulate carrier material for contrast agents have received considerable attention the past few years, since the material holds great promise for biomedical applications. A key feature for successful application of this material in vivo is biocompatibility, which may be significantly improved by appropriate surface modification. In this study, we report a novel strategy to coat silica particles with a dense monolayer of paramagnetic and PEGylated lipids. The silica nanoparticles carry a quantum dot in their center and are made target-specific by the conjugation of multiple alphavbeta3-integrin-specific RGD-peptides. We demonstrate their specific uptake by endothelial cells in vitro using fluorescence microscopy, quantitative fluorescence imaging, and magnetic resonance imaging. The lipid-coated silica particles introduced here represent a new platform for nanoparticulate multimodality contrast agents.
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The Mac
@TheMac
22 November, 04:27
In response The Mac to his Publication
Malignant hyperthermia has been an iatrogenic syndrome which was usually fatal. The syndrome occurs when certain physiologically active compounds act on defective skeletal and cardiac muscle cells. The syndrome consists of a soaring fever, severe acidosis, tachycardia, tachypnea, and usually myoclonic spasms. Cardiac arrhythmias, shock, bleeding disorders, and death soon follow. Malignant hyperthermia has characteristically complicated the administrations of anesthesiologists, but is being triggered by drugs used in other diagnostic and therapeutic activities. This paper reports a fatal case which followed the infusion of iodinated contrast media.
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The Mac
@TheMac
22 November, 04:28
In response The Mac to his Publication
The increased release of epinephrine and the production of fibrin split products seen in an iodinated contrast media reaction suggest certain commonalities between it and a malignant hyperthermia reaction which may be triggered be epinephrine and is complicated by disseminated vascular clotting and bleeding disorders. The potential for successful treatment has greatly improved with the availability of dantrolene. Increased awareness of the syndrome, temperature monitoring, early diagnosis, and rapid treatment should make this malignant disorder less threatening.
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The Mac
@TheMac
22 November, 04:33
In response The Mac to his Publication
Iron oxide nanoparticles, with their superparamagnetic properties, are used in a rapidly expanding number of applications, such as for cell labeling, separation, and tracking; for therapeutic agents in cancer therapy; and for diagnostic agents
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The Mac
@TheMac
22 November, 04:34
In response The Mac to his Publication
Superparamagnetic iron oxide MR imaging contrast agents have been the subjects of extensive research over the past decade. The iron oxide particle size of these contrast agents varies widely, and influences their physicochemical and pharmacokinetic properties, and thus clinical application. Superparamagnetic agents enhance both T1 and T2/T2* relaxation.
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The Mac
@TheMac
22 November, 04:35
In response The Mac to his Publication
T1 (longitudinal relaxation time) is the time constant which determines the rate at which excited protons return to equilibrium. It is a measure of the time taken for spinning protons to realign with the external magnetic field.
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The Mac
@TheMac
22 November, 04:36
In response The Mac to his Publication
This paper describes reversible “on–off” switching of the photoluminescence (PL) intensity of CdSe quantum dots (QDs), mediated by photochromic furylfulgide carboxylate (FFC) molecules chemisorbed to the surfaces of the QDs. Repeated cycles of UV and visible illumination switch the FFC between “closed” and “open” isomers. Reversible switching of the QDs’ PL intensity by >80% is enabled by different rates and yields of PL-quenching photoinduced electron transfer (PET) from the QDs to the respective isomers. This difference is consistent with cyclic voltammetry measurements and density functional calculations of the isomers’ frontier orbital energies. This work demonstrates fatigue-resistant modulation of the PL of a QD-molecule complex through remote control of PET. Such control potentially enables applications, such as all-optical memory, sensing, and imaging, that benefit from a fast, tunable, and reversible response to light stimuli.
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The Mac
@TheMac
22 November, 04:42
In response The Mac to his Publication
Quantum dots (QDs) are a subset of nanoparticles and given their properties, can be used as fluorescent NIR probes, as an alternative to organic dyes.
QDs are typically inorganic semiconductor nanoparticles, with the exception of carbon QDs, with sizes usually below 50 nm. The distinct optical properties observed in these compounds, when compared with their bulk counterparts, are due to the existence of quantum confinement effects. The quantum confinement effects that are observed are directly influenced by the material's composition and physical dimensions.
QDs are typically inorganic semiconductor nanoparticles, with the exception of carbon QDs, with sizes usually below 50 nm. The distinct optical properties observed in these compounds, when compared with their bulk counterparts, are due to the existence of quantum confinement effects. The quantum confinement effects that are observed are directly influenced by the material's composition and physical dimensions.
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The Mac
@TheMac
22 November, 04:42
In response The Mac to his Publication
In bulk semiconductor materials there is a band-gap energy (Eg) that represents the difference between the highest occupied energy state of the valence band and the lowest unoccupied state of the conduction band. When an electron in the valence band absorbs a photon with energy equal to, or higher than Eg, it becomes excited and transitions to the conduction band. This leaves behind an “electron hole.” The negatively charged electron and the positively charged hole form a quasi-particle called an exciton. When the electron relaxes back to the valence band, it annihilates the exciton and may release energy in the form of a photon, with energy lower than Eg (due to energy lost in the transition), in a process called radiative recombination.
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In the solid-state physics of semiconductors, carrier generation and carrier recombination are processes by which mobile charge carriers (electrons and electron holes) are created and eliminated. Carrier generation and recombination processes are fundamental to the operation of many optoelectronic semiconductor devices, such as photodiodes, light-emitting diodes and laser diodes. They are also critical to a full analysis of p-n junction devices such as bipolar junction transistors and p-n junction diodes.
The electron–hole pair is the fundamental unit of generation and recombination in inorganic semiconductors, corresponding to an electron transitioning between the valence band and the conduction band where generation of electron is a transition from the valence band to the conduction band and recombination leads to a reverse transition.
The electron–hole pair is the fundamental unit of generation and recombination in inorganic semiconductors, corresponding to an electron transitioning between the valence band and the conduction band where generation of electron is a transition from the valence band to the conduction band and recombination leads to a reverse transition.
04:44 AM - Nov 22, 2021
In response The Mac to his Publication
Only people mentioned by TheMac in this post can reply
The Mac
@TheMac
22 November, 04:45
In response The Mac to his Publication
photodiode
/ˌfəʊtəʊˈdʌɪəʊd/
noun
a semiconductor diode which, when exposed to light, generates a potential difference or changes its electrical resistance.
/ˌfəʊtəʊˈdʌɪəʊd/
noun
a semiconductor diode which, when exposed to light, generates a potential difference or changes its electrical resistance.
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The Mac
@TheMac
22 November, 04:46
In response The Mac to his Publication
There has been much work towards improving infrared photodetectors for telecommunication and spectroscopy, such as indium gallium arsenide (InGaAs) detectors, mercury cadmium telluride detectors, quantum-confined material detectors, etc. However, the performance of these detectors is degraded by factors including difficulty of material growth, requirement of cooling, low quantum efficiencies, or large dark current [1]. On the other hand, silicon (Si) photodetectors can have high detection efficiency, low dark currents, and excellent timing resolution, even at room temperature [2].
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