The Mac
@TheMac
31 October, 06:15
Have they locked up Joe Biden for cheating yet?
What about the corrupt Hillary Clinton?
Or even Prince Andrew?
If not why not because nobody is above the law.
What about the corrupt Hillary Clinton?
Or even Prince Andrew?
If not why not because nobody is above the law.
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Paul Robb
@Keeperoffools3
31 October, 06:17
In response The Mac to his Publication
Blind justice will reign, after the storm
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The Mac
@TheMac
31 October, 06:20
In response Paul Robb to his Publication
During a cytokine storm, various inflammatory cytokines are produced at a much higher rate than normal. This overproduction of cytokines causes positive feedback on other immune cells to occur, which allows for more immune cells to be recruited to the site of injury that can lead to organ damage.
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The Mac
@TheMac
31 October, 06:25
In response The Mac to his Publication
The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as well as the electron transporters ubiquinone and cytochrome c. There are two electron transport pathways in the ETC: Complex I/III/IV, with NADH as the substrate and complex II/III/IV, with succinic acid as the substrate. The electron flow is coupled with the generation of a proton gradient across the inner membrane and the energy accumulated in the proton gradient is used by complex V (ATP synthase) to produce ATP.
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The Mac
@TheMac
31 October, 06:25
In response The Mac to his Publication
The first part of this review briefly introduces the structure and function of complexes I‑IV and ATP synthase, including the specific electron transfer process in each complex. Some electrons are directly transferred to O2 to generate reactive oxygen species (ROS) in the ETC. The second part of this review discusses the sites of ROS generation in each ETC complex, including sites IF and IQ in complex I, site IIF in complex II and site IIIQo in complex III, and the physiological and pathological regulation of ROS. As signaling molecules, ROS play an important role in cell proliferation, hypoxia adaptation and cell fate determination, but excessive ROS can cause irreversible cell damage and even cell death.
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The Mac
@TheMac
31 October, 06:25
In response The Mac to his Publication
The occurrence and development of a number of diseases are closely related to ROS overproduction. Finally, proton leak and uncoupling proteins (UCPS) are discussed. Proton leak consists of basal proton leak and induced proton leak. Induced proton leak is precisely regulated and induced by UCPs. A total of five UCPs (UCP1‑5) have been identified in mammalian cells. UCP1 mainly plays a role in the maintenance of body temperature in a cold environment through non‑shivering thermogenesis. The core role of UCP2‑5 is to reduce oxidative stress under certain conditions, therefore exerting cytoprotective effects. All diseases involving oxidative stress are associated with UCPs.
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The Mac
@TheMac
31 October, 06:27
In response The Mac to his Publication
"Some electrons are directly transferred to O2 to generate reactive oxygen species (ROS) in the ETC."
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The Mac
@TheMac
31 October, 06:29
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:29
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:30
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:31
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:32
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:32
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:33
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:33
In response The Mac to his Publication
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Reactive oxygen species (ROS) generation is of intense interest because of its crucial role in many fields. Here we demonstrate that MoS2-QDs exhibit a promising capability for the generation of reactive oxygen species, which leads to enhanced chemiluminescence. We discovered that the unique performance is due to hydroxyl radical activation increasing the active catalytic sites on molybdenum sulphide quantum dots (MoS2-QDs). The reactive oxygen species, such as hydroxyl radicals (˙OH), superoxide radicals (˙O2−) and singlet oxygen (1O2) have been efficiently generated from H2O2 solution in alkaline conditions. In particular, the maximum ˙OH yield was enhanced significantly (9.18 times) compared to the Fe(II)/H2O2 Fenton system under neutral conditions. These findings not only enrich our understanding of the fascinating performance of MoS2 QDs, but also provide a new pathway for ROS generation in all kinds of pH
06:35 PM - Oct 31, 2021
In response The Mac to his Publication
Only people mentioned by TheMac in this post can reply
The Mac
@TheMac
31 October, 06:35
In response The Mac to his Publication
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The Mac
@TheMac
31 October, 06:36
In response The Mac to his Publication
"compared to the Fe(II)/H2O2 Fenton system under neutral conditions."
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