by Y Mei · 2012 · Cited by 68 · Related articles
4 Apr 2012 — Both lentivirus and adeno- associated virus (AAV) vectors have been used to deliver optogenetic constructs into genetically ...

by KA McGuire · 2011 · Cited by 73 · Related articles
We demonstrate that ROS are produced within minutes of adenovirus type 5 (Ad5) infection of macrophages and that oxidative stress supports ...

by G Bjørklund · 2020 · Cited by 25 · Related articles
5 Feb 2020 — Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and ...

https://bmcneurosci.biomed...

https://www.ncbi.nlm.nih.g...

by EA Ferenczi · 2019 · Cited by 22 · Related articles
11 Sept 2019 — It is also possible to express optogenetic constructs in neonatal and adult primary ventricular cardiomyocytes using viral vector ...

Of the many viruses screened, adenovirus 36 has been found to be a strong candidate virus that is associated with obesity, based on evidence in various model systems as well as clinical data. The mechanism of how the adenovirus could lead to obesity is not known and this paper proposes some new insights into how oxidative stress could be a possible mechanism of how adenovirus might lead to obesity. This paper reviews the relevant literature of both the effect of adenovirus on cells' anti-oxidant response and the link between obesity and oxidative stress.

"Our results suggest that oxidative stress may be partly responsible for the toxicity of adenovirus transduction."

https://jvi.asm.org/conten...

https://www.sciencedirect....

"Concordantly, E1A sensitized cells to the cytotoxic effects of oxidative stress and enhanced the accumulation of reactive oxygen species in response to pro-oxidant challenge. These results demonstrate that expression of E1A impedes the cellular response to oxidative stress, including the induction of ferritin."

Research in Alzheimer disease has recently demonstrated compelling evidence on the importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative stress is an event that precedes the appearance of the hallmark pathologies of the disease, neurofibrillary tangles, and senile plaques.

A viral infection that involves virus invasion, protein synthesis, and virion assembly is typically accompanied by sharp fluctuations in the intracellular levels of metabolites. Under certain conditions, dramatic metabolic shifts can result in various types of cell death. Here, we review different types of adenovirus-induced cell death associated with changes in metabolic profiles of the infected cells.

As evidenced by experimental data, in most cases changes in the metabolome precede cell death rather than represent its consequence. In our previous study, the induction of autophagic cell death was observed following adenovirus-mediated lactate production, acetyl-CoA accumulation, and ATP release, while apoptosis was demonstrated to be modulated by alterations in acetate and asparagine metabolism.

On the other hand, adenovirus-induced ROS production and ATP depletion were demonstrated to play a significant role in the process of necrotic cell death. Interestingly, the accumulation of ceramide compounds was found to contribute to the induction of all the three types of cell death mentioned above. Eventually, the characterization of metabolite analysis could help in uncovering the molecular mechanism of adenovirus-mediated cell death induction and contribute to the development of efficacious oncolytic adenoviral vectors.

Oxidative stress is involved in the pathogenesis of many diseases. Overexpression of antioxidant enzymes by gene therapy may protect tissues from oxidative damage. Because the reactive oxygen species hydrogen peroxide can diffuse across cell membranes, we hypothesized that overexpression of the antioxidant catalase within certain cells might protect neighboring cells.

To test this hypothesis, we transduced retinal pigment epithelial (RPE) cells in vitro and in vivo with adenovirus carrying the catalase gene (Ad.CMV.catalase). After transduction of only a subset of RPE cells in vitro, all cells in the culture were protected from exogenous hydrogen peroxide. Similarly, in vivo, eyes injected with Ad.CMV.catalase had high catalase levels in the RPE, which protected the adjacent

photoreceptors from light damage and reduced photoreceptor oxidative stress

as measured by the markers 4-hydroxynonenal and nitrotyrosine.

Opsins are a group of proteins made light- sensitive via the chromophore retinal (or a variant) found in photoreceptor cells of the retina.

Quantum effect

While in the retina, the nanoparticles are stimulated by visible light entering the eye – and if a quantum dot is stimulated while it is in close proximity to a neural cell, it triggers an action potential in that cell which is interpreted as vision by the brain.

by A Khatchadourian · 2009 · Cited by 46 · Related articles
Certain nanoparticles can induce lipid droplet formation under oxidative stress conditions.

by V Kumar · 2018 · Cited by 12 · Related articles
Many recently published reports have shown that nanoparticles impart oxidative stress and cellular damage in plant systems and in response, ...

Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals

Role of oxidative stress in nanoparticles toxicity
by M Horie · 2020 · Related articles
18 Dec 2020 — Various types of nanoparticles are known to induce oxidative stress by generating intracellular reactive oxygen species ( ROS).

ROS in apoptosis and cell survival. Disproportional increase in intracellular ROS can induce cancer cell cycle arrest, senescence and apoptosis. This can be achieved with cancer chemotherapy, depletion of cells from antioxidant proteins or generation of ROS by immune cells.

Reactive oxygen species in cancer
by GY Liou · 2010 · Cited by 1968 · Related articles
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumor ...

Photosynthesis is a well-established source of reactive oxygen species (ROS) in plants. The photosynthetic electron transport chain (PET) operates in an aerobic environment; thus, regulatory systems are required to minimize ROS production.

Scientists have found that a virus can stimulate photosynthesis in bacterial hosts. The work, which was performed at the University of Kaiserslautern and Ruhr University Bochum was reported in the Journal of Biological Chemistry.
26 Feb 2017