A 2025 experimental study in Nature revealed how aspirin can suppress cancer metastasis.
Platelets release thromboxane A2 (TXA2), which binds CD8+ T cells and activates ARHGEF1, suppressing T-cell function and preventing immune-mediated tumor clearance.
Researchers used mouse models of melanoma and lung cancer, showing that blocking platelet COX-1 with aspirin or deleting ARHGEF1 in T cells reactivated cytotoxic T cells, dramatically reducing metastases. This effect was immune-dependent: mice lacking functional T cells showed no benefit.
These findings provide a mechanistic explanation for decades of clinical observations linking low-dose aspirin to reduced cancer spread. Targeting the TXA2–COX-1–ARHGEF1 axis may guide future immunotherapies against metastasis.
Platelets release thromboxane A2 (TXA2), which binds CD8+ T cells and activates ARHGEF1, suppressing T-cell function and preventing immune-mediated tumor clearance.
Researchers used mouse models of melanoma and lung cancer, showing that blocking platelet COX-1 with aspirin or deleting ARHGEF1 in T cells reactivated cytotoxic T cells, dramatically reducing metastases. This effect was immune-dependent: mice lacking functional T cells showed no benefit.
These findings provide a mechanistic explanation for decades of clinical observations linking low-dose aspirin to reduced cancer spread. Targeting the TXA2–COX-1–ARHGEF1 axis may guide future immunotherapies against metastasis.
05:16 AM - Dec 29, 2025
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Myra Raney
@myralynnr
29 December, 05:17
In response Myra Raney to her Publication
Bottom Fact : Aspirin reduces cancer metastasis by blocking platelet TXA2, lifting T-cell suppression, and restoring immune-mediated tumor cell killing in preclinical models.
Source : Nature (2025) Experimental study on platelet-mediated immune suppression and aspirin in mouse cancer models
Disclaimer : This content is for educational purposes. Findings are preclinical; aspirin’s effects in humans for metastasis prevention require clinical confirmation and professional medical guidance.
Source : Nature (2025) Experimental study on platelet-mediated immune suppression and aspirin in mouse cancer models
Disclaimer : This content is for educational purposes. Findings are preclinical; aspirin’s effects in humans for metastasis prevention require clinical confirmation and professional medical guidance.
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