Noticed the icky suffocating feeling synthetics had on my skin 50 years ago. Whenever I have to wear some synthetic shirt for identification or whatever I will always put a cotton t-shirt under it no matter how hot it is.
Though pricey I invested in a wool set of thermal underwear last winter and absolutely love them. Have become my goto lounging around the house attire on cooler days. They came with a pair of thin wool socks too ... nice!