TITANIUM HYPERSENSITIVITY ...
or is it ... Titanium TOXICITY ?
Keywords: auto-immune inflammatory syndrome, spinal implants, titanium hypersensitivity, metal allergy
In patients with metal hypersensitivity reactions, various imaging demonstrated peri-prosthetic tissue swelling with or without implant loosening [8-9,11]. Peri-prosthetic tissue samples consistently demonstrate a predominance of lymphocyte proliferation [8]. However, the reaction may not remain a local phenomenon. Elevated metal ion serum levels are associated with instrumented spinal fusion [12]. Metallic particles have also been located within lymph nodes, liver, and spleen [13]. Heavy and transition metals such as titanium bind to sulfur within the mitochondria inducing free radical formation triggering inflammatory, autoimmune and hypersensitivity reactions [14]. Chronic metal induced inflammation may initiate or aggravate non-specific systemic symptoms and may be attributed to auto-immune/inflammatory syndrome i
or is it ... Titanium TOXICITY ?
Keywords: auto-immune inflammatory syndrome, spinal implants, titanium hypersensitivity, metal allergy
In patients with metal hypersensitivity reactions, various imaging demonstrated peri-prosthetic tissue swelling with or without implant loosening [8-9,11]. Peri-prosthetic tissue samples consistently demonstrate a predominance of lymphocyte proliferation [8]. However, the reaction may not remain a local phenomenon. Elevated metal ion serum levels are associated with instrumented spinal fusion [12]. Metallic particles have also been located within lymph nodes, liver, and spleen [13]. Heavy and transition metals such as titanium bind to sulfur within the mitochondria inducing free radical formation triggering inflammatory, autoimmune and hypersensitivity reactions [14]. Chronic metal induced inflammation may initiate or aggravate non-specific systemic symptoms and may be attributed to auto-immune/inflammatory syndrome i
Rare Systemic Response to Titanium Spinal Fusion Implant: Case Report - PMC
Neurosurgical patients with titanium spinal implant hypersensitivity can be difficult to diagnosis due to its rarity. Suspicion for titanium allergy is generally localized to the hardware site and may initially be thought to be an infectious process. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100857/
12:40 PM - Apr 01, 2024
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