As the most significant orthopoxvirus infection in humans in the smallpox post-eradication era, monkeypox is an emerging zoonotic disease. Monkey pox has a clinical appearance that is comparable to smallpox's. Monkeypox has a case fatality rate of 10%, which is in between Variola major's case fatality rate of 30% and Variola minor's case fatality rate of 10%. The monkeypox virus is regarded as a highly dangerous pathogen that causes a disease that is significant for public health.

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