Gene expression and therapy is the introduction of foreign nucleic acids into target cells to modify or compensate for gene defects, so as to treat diseases such as cancer, diabetes, autoimmune diseases and infectious diseases. The rate of removal of exposed nucleic acid is faster, and the rate of non-specific biological distribution and cell internalization is low, which cannot achieve the expected therapeutic effect. Non-viral vectors have low immunity, can be used for multiple injections and mass production, and have great potential for clinical gene therapy. Common non-viral vector transgenic methods include electroporation, calcium phosphate precipitation, and liposomes. https://www.cd-bioparticle...

DiagPoly™ Amine Poly(Methyl Methacrylate) PMMA Particles, Porous, 15 μm
Amine porous Poly(Methyl Methacrylate) PMMA particles, 15 μm, 1.2 g/mL, supplied in DI water, sterilized. https://www.cd-bioparticle...

DiagPoly™ Plain Polystyrene Particles, 20 μm
Plain PS Particles, 20 μm, 10 mg/mL, supplied in DI water.

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CD Bioparticles offers custom surfaces of drug carriers by utilizing new coatings and modification techniques to overcome some limits by conventional modification. These drug loaded particles have longer blood circulation time and greater opportunity for specific localization with the existence of new coatings or modification like glycans, polyketals, polyvinylpyrrolidone, red cell membranes and so on. https://www.cd-bioparticle...

DiagNano™ Water Dispersible Upconverting Nanoparticles, 804 nm
Water dispersible upconverting nanoparticles, absorbance max 975 nm, emission max 804 nm, White crystalline solid, Purity:>95.0%. NaYF4:Yb, Tm, Mn
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Absolute Mag™ Fe(III) Oxide Hydroxide Nanorods in Ethanol, 50 wt%, 100 nm x 500 nm
Fe2O3H2O Nanorods Ethanol Dispersion, Alpha, 98%, Diameter 100 nm, Length 500 nm, 50wt% in Ethanol
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A fully validated dissolution in vitro release method is one of the control tools to ensure that quality and clinical performance are maintained throughout the lifecycle of the drug products. For example, in vitro release methods may aid in the characterization of liposome integrity, and in quantifying free versus encapsulated drugs. Like drug products without nanomaterials, drug products containing nanomaterials should have dissolution/in vitro release methods capable of discriminating formulation and manufacturing differences which may impact the clinical performance of the drug product. In addition to in vitro drug release, drug in vitro testing also includes in vitro toxicity test, in vitro drug sensitivity tests and so on. https://www.cd-bioparticle...

CD Bioparticles offers custom ultrasound imaging contrast agents with ideal contrast properties to meet all your ultrasound imaging needs. With years of expertise in diagnosis and imaging contrast agents development, our experienced scientists can construct both microbubble and inorganic nanoparticles-based contrast agents tailored for ultrasound imaging. https://www.cd-bioparticle...

The pull-down assay is a technique developed to verify the physical interactions between proteins in vitro, which can be also used to confirm a predicted protein-protein interaction and identify novel interacting partners. Although this method can't reflect the real interaction under physiological conditions due to the uncertain spatially encounter in vivo, it is a powerful tool for studying protein-protein interactions in vitro. This method typically involves the affinity capture process using bait protein coupled supports and various wash and elution steps, which are tedious and time-consuming. https://www.cd-bioparticle...

The main ingredient of this product is HAMA (methacrylated hyaluronic acid, molecular weight 150k-250kDa), has good biocompatibility, can be stimulated by ultraviolet light or visible light (blue light), and can be mixed with basic biological materials or other bio-inks of Shangpu to form a three-dimensional structure suitable for cell growth and differentiation with a certain strength. https://www.cd-bioparticle...

Color-dyes polystyrene particles conjugated with recognition molecules as antibodies, antigens, proteins, or other biomacromolecules are available on request. Unmodified polymer spheres are also offered. These polymer particles find extensive applications in a range of flow assays, diagnostic tests, optical and electronic instrument testing, and calibration. https://www.cd-bioparticle...

CD Bioparticles provide a wide range of uniform and monodisperse colored polystyrene particles. Our colored particles are prepared by polymerizing styrene in oil soluble dye solution in styrene. Therefore, the particles do not contain the solvents commonly found in the preparation of particles by staining with dye solutions in organic solvents. Diagpoly™ Colored Polystyrene Particles are intensely colored, which can enhance the visual detection in assays such as latex agglutination, dipstick, and membrane-based assays. https://www.cd-bioparticle...

Silane-PEG-Maleimide (Silane-PEG-Mal) is a linear heterobifunctional PEG reagent with a maleimide and a silane.It is a useful crosslinking reagent with a PEG spacer. Maleimide reacts with thiol, SH, sulfhydryl or mercapto, and silane group can react with glass or other hydroxylated surface or particle.It may be used to introduce thiol or cysteine reactive functional group on hydroxylated nanopartilce, microsphere, self-assembled monolayer or metal chips. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.
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1,1'-(1,4-phenylene)diurea

Catalog:CDM-CH1357

Unit Size:5 g
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Type I rat tail telocollagen solution is for 2D coatings or 3D hydrogels. The product is soluble telo-collagen and is provided in a 0.02M acetic acid solution (~pH 3). Each product includes a bottle of collagen solution. This product is sterile filtered and is ideal for coating of surfaces, providing preparation of thin layers for culturing cells, or use as a solid gel. This product is for R&D use only and is not intended for human or other uses. https://www.cd-bioparticle...

Absolute Mag™ DNA Magnetic Particles, Silica-coated, 1.0 μm (#WHM-G180) are superparamagnetic particles with porous silica coating. These particles are designed for automatic DNA/RNA separation such as genomic DNA, plasmid DNA, total RNA and PCR products. DNA/RNA bind to these porous silica surface under high salts conditions (5 M guanidinium thiocyanate). https://www.cd-bioparticle...

Basic magnetic particles can be further coated and functionalized for biotechnology and biomedical applications. In vitro, magnetic beads are widely used in diagnostic and separation of biomolecules, such as protein, cell, DNA/RNA, microorganism. In vivo, magnetic beads have been used both in therapeutic (drug delivery and hyperthermia) and diagnostic applications (magnetic resonance imaging(MRI)). https://www.cd-bioparticle...

CD Bioparticles offers unmodified magnetic particles to meet our customers’multiple needs. The magnetic functionality of magnetic particles is determined by composition, size, and shape of its magnetic core. These cores can be made from different materials and with varying sizes, shapes, uniformities, and magnetic properties. Our scientists are experts in preparing magnetic particles in various forms, including pureiron and cobalt metals, alloys such as CoPt3, FePt,FeZn, iron oxides which includes magnetite (Fe3O4) and maghemite (γ-Fe2O3). We also dope iron oxides with Mn, Fe, Co or Nito form MFe2O4 structures and enhance their magnetic properties. https://www.cd-bioparticle...

Lipid PEGs
PEG lipids, also known as PEGylated lipids, are a class of PEG derivatives. PEG lipids have been widely used to improve the circulation time of liposome-encapsulated (LNP) drugs and reduce nonspecific uptake. The design flexibility of PEG lipids and the simplicity of physical drug entrapment make PEG-lipid micelles a versatile and effective drug carrier for cancer therapy. They have been shown to overcome some of the limitations of poorly soluble drugs, such as non-specific biodistribution and targeting, lack of water solubility, and poor oral bioavailability. CD Bioparticles offers a wide range of polyethylene glycol-lipid conjugates, including various functionalized polyethylene glycol ends such as amines, carboxylic acids, azides, aldehydes, thiols and hydroxyls. In addition, we also provide a choice of different lipids, such as Cholesterol, DOPE, DSPE, and DBCO, etc. https://www.cd-bioparticle...

VHL Ligand 1 (hydrochloride)

VHL Ligand 1 HCl

Catalog:CDPB-05021

Unit Size:250 mg, 500 mg, 1 g
Common Use: VHL Ligand 1 HCl salt is a synthetic compound that incorporate an E3 ligase ligand with and a PEG linkers to empower PROTAC drug research & discovery. PEG spacer increase aqueous solubility. https://www.cd-bioparticle...

NO2-MIL-101 (Cr)
Synonym: IRMOF-1
Common Use: Gas adsorption and separation, drug delivery
Appearance: White Powder
Storage: Store at room temperature or 4 °C in dry-state. Recommend to be activated at 100 ℃ in a vacuum oven for 3 hours before use
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CD Bioparticles offers a range of coloured silica particles, which have narrow size distribution yet multiple size selection from 100 nm to 100 µm. Unlike fluorescent silica particles, these coloured silica particles do not emit fluorescence and can be easily viewed by the naked eye. Red and blue particles are available with covalently bound dyes in silica matrix, which are extremely stable in organic solvents and buffers. Black silica particles are available with a coating of black ink, that is stable in aqueous media, but not in organic solvents.

The coloured silica particles we provide have a hydrophilic surface with terminal hydroxyl or amine groups, which are used for the conjugation of proteins, antibodies, oligonucleotides and other molecules. https://www.cd-bioparticle...

CD Bioparticles offers a range of basic silica particles in a variety of sizes, which have a hydrophilic surface with terminal hydroxyl groups without any additional functional groups on the surface. The hydroxyl groups give silica colloids a large negative zeta potential at neutral and basic pH.
Since the presence of a large number of hydroxyl groups in different states on the particle surface makes the silica particles hydrophilic, oleophobic and easy to agglomerate, it is necessary to functionally modify them to improve the performance and application range. Silica surfaces are versatile and can be easily modified to attach specific functional groups. In addition, the nanoporous structure of silica allows moderate molecular weight molecules, such as fluorophores, to be loaded into the silica shell. https://www.cd-bioparticle...

CD Bioparticles provides silica particles with a high amount of covalently bound fluorescence dye in the silica matrix. The fluorescent silica particles we offer consist of ultra-monodisperse spherical silica particles loaded with a fluorescent dye, providing fluorescence capabilities comparable to heavy metal quantum dots (which are generally classified as toxic), with excitation/emission values dependent on the dye/color. Dye-doped silica particles allow different dyes and drugs to be accommodated in the silica matrix while still allowing control over the resulting particle size and shape. Furthermore, their adaptable and well-understood chemistry allows simple and straightforward modifications of particle surface chemistry, providing reactive sites for further functionalization. https://www.cd-bioparticle...

HP-β-CD-C3N4 Hydroxypropyl-Beta Cyclodextrin-Carbonide Fluorescent Nanomaterials
Catalog:CYCL278
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Azido-PEG1-CH2CO2H is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. https://www.cd-bioparticle...

Poly(D-lactide)
PDLA
Catalog:CDP157
Unit Size:1 g
Solid phase drug delivery/implantable systems
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CD Bioparticles provides a comprehensive list of upconverting nanoparticles (UCNPs) which are doped with lanthanide ions. Through judicious selection of lanthanide dopants, UCNPs can display wavelength (color) selective upconversion, such as NIR to shorter NIR, visible (blue, green, red), or UV. Upconverting nanoparticles have favorable properties of nonblinking, nonphotobleaching, high chemical stability, sharp emission bands, NIR light excitation, and large anti-Stokes emissions. https://www.cd-bioparticle...

Due to unique physical and chemical properties (including optical, electrical and thermal, high electrical conductivity and biological properties), silver nanoparticles (AgNPs) are increasingly used in various fields including medical, food, healthcare, consumer and industrial, as antibacterial agents, medical device coatings, optical sensors, anticancer agents, etc. Its applications in the life sciences and medicine have focused on antibacterial, antifungal, antiviral, anti-inflammatory, anticancer, and antiangiogenic properties.

CD Bioparticles provides a comprehensive list of silver nanoparticles with different surface properties in multiple sizes. Silver nanoparticles produced with our proprietary protocols are highly monodisperse with a narrow size distribution. https://www.cd-bioparticle...