Many commonly used medical devices, such as catheters, extracorporeal circulation systems, and endovascular grafts, come into contact with circulating blood. Therefore, before submitting these devices to regulatory authorities for approval, their haemocompatibility, such as the risk of hemolysis and thrombosis, needs to be evaluated. The tests required for the evaluation depend on the type and duration of contact for the specific medical device involved (ISO10993-4 Biological evaluation of medical devices Part 4: Selection of tests for interaction with blood). https://biocoating.cd-biop...

In order to protect humans from potential biological risks arising from the use of medical devices, international standards, national standards and guidelines provide guidance on the overall evaluation of various medical devices and the biological evaluation of the development process. As a crucial part of biological evaluation, in vitro cytotoxicity evaluation often provides important guidance for how to conduct the next biological evaluation. The International Organization for Standardization (ISO) and the United States Pharmacopeia (USP) have established special evaluation methods for cytotoxicity testing (ISO 10993-5, ISO 7405, USP General Chapter 87). https://biocoating.cd-biop...

Systemic toxicity is the potential adverse effect of medical devices caused by leachable substances of the product or its materials during use. This is because these leachable substances may produce general systemic toxic effects on tissues or organs that are not in direct contact with the product through absorption, distribution and metabolism. Systemic toxicity includes acute toxicity, subacute toxicity, subchronic toxicity and chronic toxicity tests. https://biocoating.cd-biop...

Disposable hemoperfutor is a medical device made of adsorbent such as activated carbon or adsorbent resin, which is mainly used in conjunction with blood purification device for blood perfusion treatment. It is capable of removing endogenous and exogenous drugs, poisons and metabolites from the patient's body, which is of great significance in the treatment of poisoning, drug overdose, liver failure, renal failure, and many other diseases. https://biocoating.cd-biop...

Closure set, in the medical field, primarily refers to a collection of devices and materials that are used to close, seal, or immobilize medical passages, wounds, incisions, and other areas. The purpose is to reduce bleeding from wounds or incisions and reduce surgical risk through suturing, closure, etc. https://biocoating.cd-biop...

Absolute Mag™ Anti-C-tag Magnetic Particles, 2 μm
2 μm magnetic particles conjugated to the anti-C-tag antibody. They can be used for the purification of C-terminal tagged proteins. Supplied as lyophilized powder. https://www.cd-bioparticle...

Protein G magnetic particles are a type of biomagnetic separation technology used for protein purification and analysis. These particles are coated with Protein G, an antibody-binding protein that can specifically bind to the constant region of immunoglobulins (IgGs). Because antibodies are often used in research and diagnostic applications, Protein G magnetic particles can be used to purify and isolate antibodies from complex mixtures such as cell lysates, serum, or ascites fluid. The magnetic properties of the particles allow for easy capture and separation by applying a magnetic field. https://www.cd-bioparticle...

Medical device OEM products are widely used in the medical field, including but not limited to diagnostic, therapeutic, rehabilitation, etc. These products usually have high quality, high performance and reliability to meet the needs of medical institutions and patients. These products usually have high quality, high performance and reliability to meet the needs of medical institutions and patients. https://biocoating.cd-biop...

Embolization microspheres are a widely used medical device in the medical field, mainly for vascular embolization therapy. It can be used to treat a variety of diseases, such as aneurysms, vascular malformations, primary liver cancer, liver metastatic cancer and other fine embolization therapy. By blocking the blood vessels in the diseased area and reducing or stopping the blood supply, it helps to shrink or eliminate the lesion and alleviate the related symptoms. https://biocoating.cd-biop...

Chitosan is labeled with Fluorescein. Lyophilized powder. The product is furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. https://www.cd-bioparticle...

NHS-activated magnetic particles are magnetic beads coated with a high density of NHS (N-hydroxylsuccinimide) functional groups on the surface. NHS-activated magnetic particles have shown important value in couple to proteins or other ligands with amino-functionalities. Especially, some particles are used to specifically conjugate primary amine-containing targeted protein or ligands in a simple mix-and-go format for use in custom affinity purification experiments with significant low non-specific binding. https://www.cd-bioparticle...

Octadecyl (C18) magnetic particles are magnetic beads coated with a high density of octadecyl (C18) functional groups on the surface. Hydrophobic magnetic particles are useful tool for the magnetic separation of biomolecules based on interactions of external hydrophobic regions of proteins, peptides, enzymes or nucleic acids. https://www.cd-bioparticle...

These dextrans with antibody covalently linked to high molecular weight dextran, serve to crosslink receptors, which are the antibody target, on cell surfaces. Anti-IgD dextran is an efficient and potent polyclonal B cell activator for studying a wide range of B cell functions. https://www.cd-bioparticle...

DiagPoly™ PEG Polystyrene Particles, 10 μm
10 μm PS particles are designed with PEG 300 coating on the surface to reduce the unspecific binding of proteins significantly. These particles are supplied in water. Standard deviation < 10 % (C.V.). https://www.cd-bioparticle...

Dextran is a polysaccharide composed of D-glucose monomers linked by glycosidic bonds. The structure is rich in hydroxyl groups, making it easy to chemically modify. The active groups on glucan can simultaneously load multifunctional molecules (enzymes, antibodies, peptides, nucleic acids, etc.), facilitating the preparation of multifunctional microspheres. It has now been widely used in two-dimensional and porous soft tissue scaffolds, drug release and other fields. Additionally, dextran gel is a polymer compound with three-dimensional mesh structure. https://www.cd-bioparticle...

High purity Chitosan (CS) is extracted from Chitin. Chitosan has NH2 groups that can be used for bioconjugation or further derivatization using amide coupling reaction with carboxylic acid.
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DiagPoly™ Plain Polystyrene Particles, 0.025 μm
Plain PS Particles, 0.025 μm, 10 mg/mL, supplied in DI water.

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DiagNano™ Gold Nanoparticles, 2.2 nm
2.2 nm Au, citrate capping, DI water, 1 OD ( 0.05 mg/mL), 4.66E+14 particles/mL, Size Dispersity %PDI: < 25%, Size Accuracy (+/- nm): 0.1 nm.
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DiagNano™ Streptavidin conjugated Gold Nanoparticles, 60 nm, 10 OD

10 OD streptavidin conjugated gold nanoparticles, 60 nm, supplied in 0.01M PBS (pH 7.4), 20% glycerol (v/v), 1% BSA. https://www.cd-bioparticle...

DiagPoly™ Europium Carboxylate Polystyrene Nanoparticles, 200 nm (#DEC-T006) are polystyrene or polystyrene with coploymer grafted surface. The particles are chelated with Eu (excitation: 333 nm, emission: 613 nm, red fluorescence) for extremely broad stokes shift which can prevent non-specific fluorescence interference. 200 nm europium polystyrene nanoparticles are functionalized with carboxyl groups (COOH) and applied in lateral flow, diagnostic assay, molecular biology and other time-resolved fluorescent research. The density of particle solution is 1.06 g/cm3. Each carboxylate group will provide parking area of 20 A2 on the surface. https://www.cd-bioparticle...

Cardiolipin (CL) is a unique phospholipid with a very interesting chemical and specific ultrastructural characteristics. It is a highly acid dimer of phosphatidylglycerol (PG) and phosphatidic acid (PA), containing four acyl chains; three glycerols and two phosphate headgroups. Due to deprotonation of one of one of these phosphate groups, cardiolipin is negatively charged in physiological pH. https://www.cd-bioparticle...

Gene expression and therapy is the introduction of foreign nucleic acids into target cells to modify or compensate for gene defects, so as to treat diseases such as cancer, diabetes, autoimmune diseases and infectious diseases. The rate of removal of exposed nucleic acid is faster, and the rate of non-specific biological distribution and cell internalization is low, which cannot achieve the expected therapeutic effect. Non-viral vectors have low immunity, can be used for multiple injections and mass production, and have great potential for clinical gene therapy. Common non-viral vector transgenic methods include electroporation, calcium phosphate precipitation, and liposomes. https://www.cd-bioparticle...

DiagPoly™ Amine Poly(Methyl Methacrylate) PMMA Particles, Porous, 15 μm
Amine porous Poly(Methyl Methacrylate) PMMA particles, 15 μm, 1.2 g/mL, supplied in DI water, sterilized. https://www.cd-bioparticle...

DiagPoly™ Plain Polystyrene Particles, 20 μm
Plain PS Particles, 20 μm, 10 mg/mL, supplied in DI water.

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CD Bioparticles offers custom surfaces of drug carriers by utilizing new coatings and modification techniques to overcome some limits by conventional modification. These drug loaded particles have longer blood circulation time and greater opportunity for specific localization with the existence of new coatings or modification like glycans, polyketals, polyvinylpyrrolidone, red cell membranes and so on. https://www.cd-bioparticle...

DiagNano™ Water Dispersible Upconverting Nanoparticles, 804 nm
Water dispersible upconverting nanoparticles, absorbance max 975 nm, emission max 804 nm, White crystalline solid, Purity:>95.0%. NaYF4:Yb, Tm, Mn
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Absolute Mag™ Fe(III) Oxide Hydroxide Nanorods in Ethanol, 50 wt%, 100 nm x 500 nm
Fe2O3H2O Nanorods Ethanol Dispersion, Alpha, 98%, Diameter 100 nm, Length 500 nm, 50wt% in Ethanol
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A fully validated dissolution in vitro release method is one of the control tools to ensure that quality and clinical performance are maintained throughout the lifecycle of the drug products. For example, in vitro release methods may aid in the characterization of liposome integrity, and in quantifying free versus encapsulated drugs. Like drug products without nanomaterials, drug products containing nanomaterials should have dissolution/in vitro release methods capable of discriminating formulation and manufacturing differences which may impact the clinical performance of the drug product. In addition to in vitro drug release, drug in vitro testing also includes in vitro toxicity test, in vitro drug sensitivity tests and so on. https://www.cd-bioparticle...

CD Bioparticles offers custom ultrasound imaging contrast agents with ideal contrast properties to meet all your ultrasound imaging needs. With years of expertise in diagnosis and imaging contrast agents development, our experienced scientists can construct both microbubble and inorganic nanoparticles-based contrast agents tailored for ultrasound imaging. https://www.cd-bioparticle...

The pull-down assay is a technique developed to verify the physical interactions between proteins in vitro, which can be also used to confirm a predicted protein-protein interaction and identify novel interacting partners. Although this method can't reflect the real interaction under physiological conditions due to the uncertain spatially encounter in vivo, it is a powerful tool for studying protein-protein interactions in vitro. This method typically involves the affinity capture process using bait protein coupled supports and various wash and elution steps, which are tedious and time-consuming. https://www.cd-bioparticle...