The necessity for optical interfaces in biomedical applications is driving increasing demand for the development of biocompatible photonic components. Biophotonic components are essential for applications including sensors,[1,2] imaging,[3–6] bio-micro- electromechanical systems (MEMS) devices,[7] and therapeu- tics.[8] Silk fibroin in film form has been recently identified as a suitable biopolymer for the development of optical devices.[9,10] Biocompatible silk fibroin has promise as an optical biomaterial based on a number of important physical properties.[11] In particular, silks are the strongest and toughest natural fibers known, and regenerated silk fibroin from the Bombyx mori silkworm are easily formed into a variety of material formats such as hydrogels,[12] ultrathin and thick films,[13,14] controlled-release coatings,[15] 3D porous matrices,[16] and fibers with controllable diameters.[17]