F scumbags.

A blood clot med called Pra.... made by BI was recently approved for use in children 3 months - just under 12 years, the FDA was happy to announce.
Why are children at risk for blood clots now?
F indeed.

First, we assessed bimodal connectivity of structurally altered candidate regions using meta-analytic connectivity modeling (MACM) and resting-state correlations employing openly accessible data. We compared the ensuing connectivity maps to the activation likelihood estimation (ALE) maps of a recent quantitative meta-analysis of brain activity during processing of sexual stimuli. Second, we functionally characterized the structurally altered regions employing meta-data of a large-scale neuroimaging database. Candidate regions were functionally connected to key areas for processing of sexual stimuli.

Moreover, we found that the functional role of structurally altered brain regions in pedophilia relates to nonsexual emotional as well as neurocognitive and executive functions, previously reported to be impaired in pedophiles. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The findings moreover indicate that structural alterations account for common affective and neurocognitive impairments in pedophilia. The present multi-modal integration of brain structure and function analyses links sexual and nonsexual psychopathology in pedophilia.

The sudden and uncontrollable paedophilia exhibited by a 40-year-old man was caused by an egg-sized brain tumour, his doctors have told a scientific conference. And once the tumour had been removed, his sex-obsession disappeared.

The cancer was located in the right lobe of the orbifrontal cortex, which is known to be tied to judgment, impulse control and social behaviour. But neurologists Russell Swerdlow and Jeffrey Burns, of the University of Virginia at Charlottesville, believe it is the first reported case linking damage to the region with paedophilia.

“We’re dealing with the neurology of morality here,” says Swerdlow. Since the area does not affect physical health, “it’s one of those areas where you could have a lot of damage and a doctor would never suspect something’s wrong,” he says.

“He wasn’t faking,” says Burns. “But if someone argues that every paedophile needs a MRI, the difference in this case was that the patient had a normal history before he acquired the problem. Most paedophiles develop problems early on in life.”

Infection with the Epstein-Barr virus (EBV) increases the risk of CNS lymphoma. EBV is more commonly known as the virus that causes mononucleosis or “mono.” In other research, high levels of a common virus called cytomegalovirus (CMV) have been found in brain tumor tissue.

cytomegaloviral (not comparable)

Relating to cytomegaloviruses.

New Latin, from English cyto- (“cell”) +‎ Ancient Greek μέγας (mégas, “big, megalo-”) +‎ -virus.

Iris is a genus of 260–300[1][2] species of flowering plants with showy flowers. It takes its name from the Greek word for a rainbow, which is also the name for the Greek goddess of the rainbow, Iris. Some authors state that the name refers to the wide variety of flower colors found among the many species. As well as being the scientific name, iris is also widely used as a common name for all Iris species, as well as some belonging to other closely related genera. A common name for some species is 'flags', while the plants of the subgenus Scorpiris are widely known as 'junos', particularly in horticulture. It is a popular garden flower.

A rainbow shows up as a spectrum of light: a band of familiar colors that include red, orange, yellow, green, blue, and violet. ... Biv" is an easy way to remember the colors of the rainbow, and the order in which they appear: red, orange, yellow, green, blue, indigo, and violet.

Autism is a severe developmental disorder with poorly understood etiology. Oxidative stress in autism has been studied at the membrane level and also by measuring products of lipid peroxidation, detoxifying agents (such as glutathione), and antioxidants involved in the defense system against reactive oxygen species (ROS). Lipid peroxidation markers are elevated in autism, indicating that oxidative stress is increased in this disease. Levels of major antioxidant serum proteins, namely transferrin (iron-binding protein) and ceruloplasmin (copper-binding protein), are decreased in children with autism.

There is a positive correlation between reduced levels of these proteins and loss of previously acquired language skills in children with autism. The alterations in ceruloplasmin and transferrin levels may lead to abnormal iron and copper metabolism in autism. The membrane phospholipids, the prime target of ROS, are also altered in autism.

The levels of phosphatidylethanolamine (PE) are decreased, and phosphatidylserine (PS) levels are increased in the erythrocyte membrane of children with autism as compared to their unaffected siblings. Several studies have suggested alterations in the activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and catalase in autism. Additionally, altered glutathione levels and homocysteine/methionine metabolism, increased inflammation, excitotoxicity, as well as mitochondrial and immune dysfunction have been suggested in autism.

Furthermore, environmental and genetic factors may increase vulnerability to oxidative stress in autism. Taken together, these studies suggest increased oxidative stress in autism that may contribute to the development of this disease. A mechanism linking oxidative stress with membrane lipid abnormalities, inflammation, aberrant immune response, impaired energy metabolism and excitotoxicity, leading to clinical symptoms and pathogenesis of autism is proposed.

“I do set my bow in the cloud, and it shall be for a token of a covenant between me and the earth.”

The effects of Asperger’s and autistic spectrum disorder (ASD) on everything from depression to gender dysphoria could be being overlooked, according to a world-renowned expert on the syndrome. Tony Attwood, a clinical psychologist based in Australia, believes that more screening is needed to help people with the condition who present with other psychological problems, from anorexia nervosa to borderline personality disorder.

Most controversially, he believes society needs to tackle the taboo subject of ASD and paedophilia. Speaking ahead of World Autism Awareness Day today, he suggested that many inmates in sex offender units, including those convicted of child pornography offences, show signs of Asperger’s or ASD.

Oxidative stress plays a critical role in nanotoxicity. Various types of nanoparticles are known to induce oxidative stress by generating intracellular reactive oxygen species (ROS). Cellular uptake of nanoparticles and intracellular metal ion release are important factors for intracellular ROS generation.

Reactive oxygen species (ROS) are by-products of aerobic metabolism and can also act as signaling molecules to participate in multiple regulation of biological and physiological processes. The occurrence, growth and metastasis of tumors, and even the apoptosis, necrosis and autophagy of tumor cells are all closely related to ROS.

Summary: Pedophilia might be the result of faulty connections in the brain. A new study showed that pedophiles had significantly less "white matter." The study challenges the commonly held belief that pedophilia is brought on by childhood trauma or abuse.

Childhood adversity is a potent risk factor for mental health conditions via disruptions to stress response systems. Dysregulations in oxidative stress systems have been associated with both childhood adversity and several psychological disorders (e.g., major depressive disorder) in adult populations. However, few studies have examined associations between childhood adversity, oxidative stress, and mental health in pediatric populations.