Whispering gallery mode (WGM) resonators have attracted extensive attention and their unique characteristics have led to some remarkable achievements. In particular, when combined with optical sensing technology, the WGM reonator-based sensor offers the advantages of small size, high sensitivity and a real-time dynamic response. At present, this type of sensor is widely applied in the bio-chemical sensing field. In this paper, we briefly review the sensing principle, the structures and the sensing applications of optical bio-chemical sensors based on the WGM resonator, with particular focuses on their sensing properties and their advantages and disadvantages. In addition, the existing problems and future development trends of WGM resonator-based optical bio-chemical sensors are discussed.