The Mac
@TheMac
05 May, 06:28
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Jodie Jennings
@Jodie
05 May, 06:35
In response The Mac to his Publication
Your info is fascinating. Could you make one post and explain it further?
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The Mac
@TheMac
05 May, 06:44
In response Jodie Jennings to her Publication
🙂
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The Mac
@TheMac
05 May, 06:44
In response The Mac to his Publication
Magnetogenetics refers to a biological technique that involves the use of magnetic fields to remotely control cell activity.
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The Mac
@TheMac
05 May, 06:45
In response The Mac to his Publication
In most cases, magnetic stimulation is transformed into either force (magneto-mechanical genetics) or heat (magneto-thermal genetics), which depends on the applied magnetic field.
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The Mac
@TheMac
05 May, 06:46
In response The Mac to his Publication
Therefore, cells are usually genetically modified to express ion channels that are either mechanically or thermally gated.
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The Mac
@TheMac
05 May, 06:47
In response The Mac to his Publication
As such, magnetogenetics is a cellular modulation method that uses a combination of techniques from magnetism and genetics to control activities of individual cells in living tissue – even within freely moving animals.
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The Mac
@TheMac
05 May, 06:47
In response The Mac to his Publication
This technique is comparable to optogenetics, which is the manipulation of cell behavior using light. In magnetogenetics, magnetic stimulation is used instead of light, a characteristic that allows for a less invasive, less toxic, and wireless modulation of cell activity.
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Iron oxide (Fe₃O₄) nanoparticles (IONPs) have received much attention for their utility in biomedical applications such as magnetic resonance imaging, drug delivery and hyperthermia.
06:48 AM - May 05, 2021
In response The Mac to his Publication
Only people mentioned by TheMac in this post can reply
The Mac
@TheMac
05 May, 06:49
In response The Mac to his Publication
Recent studies reported that IONPs induced cytotoxicity in mammalian cells.
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The Mac
@TheMac
05 May, 06:50
In response The Mac to his Publication
However, little is known about the genotoxicity of IONPs following exposure to human cells. In this study, we investigated the cytotoxicity, oxidative stress and genotoxicity of IONPs in two human cell lines; skin epithelial A431 and lung epithelial A549. Prepared IONPs were polygonal in shape with a smooth surface and had an average diameter of 25 nm.
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