The Mac
@TheMac
03 April, 05:56
TiO2 NPs induced a strong oxidative stress in both glial cell lines by mediating changes in the cellular redox state and lipid peroxidation associated with a rise in the expression of glutathione peroxidase, catalase, and superoxide dismutase 2.
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Q2Infinity 5D Earth
@Patriot_iss
03 April, 05:58
In response The Mac to his Publication
Pretend I'm a 5 year old and repeat what you have said in child-like language
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The Mac
@TheMac
03 April, 06:06
In response Q2Infinity 5D Earth to her Publication
what are the symptoms of glutathione deficiency?
These problems may include seizures; a generalized slowing down of physical reactions, movements, and speech (psychomotor retardation); intellectual disability; and a loss of coordination (ataxia). Some people with severe glutathione synthetase deficiency also develop recurrent bacterial infections.
These problems may include seizures; a generalized slowing down of physical reactions, movements, and speech (psychomotor retardation); intellectual disability; and a loss of coordination (ataxia). Some people with severe glutathione synthetase deficiency also develop recurrent bacterial infections.
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The Mac
@TheMac
03 April, 06:10
In response The Mac to his Publication
The antioxidant glutathione (GSH) is essential for the cellular detoxification of reactive oxygen species in brain cells. A compromised GSH system in the brain has been connected with the oxidative stress occuring in neurological diseases.
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The Mac
@TheMac
03 April, 06:18
In response The Mac to his Publication
Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats - ScienceDirect
We studied the effect of gold nanoparticles (NPs) on oxidative stress markers including reduced glutathione (GSH) and malondialdehyde (MDA) in differe…
https://www.sciencedirect.com/science/article/pii/S1319562X12000551Notice: Undefined index: tg1tga_access in /home/admin/www/anonup.com/themes/default/apps/timeline/post.phtml on line 396
The results show that the IONP-induced oxidative stress was concentration-dependent in nature, with significant (P < 0.05) increase in ROS levels, lipid peroxidation level as well as depletion of antioxidant enzymes and glutathione. Moreover, we observed morphological changes in the cell after intracellular uptake and localization of nanoparticles in cells. From the findings of the study, it may be concluded that IONPs induce ROS-mediated cytotoxicity in lymphocytes.
06:20 PM - Apr 03, 2021
In response The Mac to his Publication
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The Mac
@TheMac
03 April, 06:24
In response The Mac to his Publication
Reactive oxygen species and thiol antioxidants, including glutathione (GSH), regulate innate immunity at various levels. This review outlines the redox-sensitive steps of the cellular mechanisms implicated in inflammation and host defense against infection, and describes how GSH is not only important as an antioxidant but also as a signaling molecule.
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The Mac
@TheMac
03 April, 06:24
In response The Mac to his Publication
There is an extensive literature of the role of GSH in immunity. Most reviews are biased by an oversimplified picture where “bad” free radicals cause all sorts of diseases and “good” antioxidants protect from them and prevent oxidative stress. While this may be the case in certain fields (eg, toxicology), the role of thiols (the topic of this review) in immunity certainly requires wearing scientist’s goggles and being prepared to accept a more complex picture.
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