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The Nuremberg Code
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The Hippocratic Oath (Modern Version)
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Hippocratic Oath
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"To practice and prescribe to the best of my ability for the good of my patients, and to try to avoid harming them."

Oxidation is a normal and necessary process that takes place in your body. Oxidative stress, on the other hand, occurs when there’s an imbalance between free radical activity and antioxidant activity. When functioning properly, free radicals can help fight off pathogens. Pathogens lead to infections.

When there are more free radicals present than can be kept in balance by antioxidants, the free radicals can start doing damage to fatty tissue, DNA, and proteins in your body. Proteins, lipids, and DNA make up a large part of your body, so that damage can lead to a vast number of diseases over time.

diabetes
atherosclerosis, or the hardening of the blood vessels
inflammatory conditions
high blood pressure, which is also known as hypertension
heart disease
neurodegenerative diseases, such as Parkinson’s and Alzheimer’s
cancer

Oxidative stress can cause chronic inflammation. Infections and injuries trigger the body's immune response. Immune cells called macrophages produce free radicals while fighting off invading germs. These free radicals can damage healthy cells, leading to inflammation.

Oxidative stress can activate a variety of transcription factors, which lead to the differential expression of some genes involved in inflammatory pathways. The inflammation triggered by oxidative stress is the cause of many chronic diseases.

Oxidation happens under a number of circumstances including: when our cells use glucose to make energy. when the immune system is fighting off bacteria and creating inflammation.

Inflammation refers to your body's process of fighting against things that harm it, such as infections, injuries, and toxins, in an attempt to heal itself. When something damages your cells, your body releases chemicals that trigger a response from your immune system.

Inflammation happens when a physical factor triggers an immune reaction.

but its a healthy normal response to the body's own ability to heal too

Infections: Illness caused by an infectious organism such as a virus or bacterium can lead to brain swelling.

Encephalitis is an uncommon but serious condition in which the brain becomes inflamed (swollen). It can be life threatening and requires urgent treatment in hospital. Anyone can be affected, but the very young and very old are most at risk.

Pneumonia is inflammation of the lungs, usually caused by an infection.

Pneumonia is an infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing. A variety of organisms, including bacteria, viruses and fungi, can cause pneumonia.

Pneumonia is one of the leading causes of neonatal respiratory distress and is most commonly acquired at birth.

Risk factors include maternal infection, preterm birth, and rupture of membranes >18 hours before delivery.28 Oct 2019

Pneumococcal meningitis can occur when the Streptococcus pneumonia bacteria invade the bloodstream, cross the blood-brain barrier and multiply within the fluid surrounding the spine and brain.

“So, if a virus can replicate in the cells of blood vessels, it has a rather direct entrance to the brain. But it could also come into the brain from cells in the blood that are allowed to cross the blood-brain barrier. It could come in through the olfactory neurons in the nose, which project to the rest of the brain.15 Jul 2020

Generally, only lipid soluble (lipophilic) molecules with a low molecular weight (under 400–600 Da) and of positive charge can cross the BBB.

Whats does soluble mean?

1 : susceptible of being dissolved in or as if in a liquid and especially water. 2 : subject to being solved or explained soluble questions.

lipid
/ˈlɪpɪd/
CHEMISTRY
plural noun: lipids
any of a class of organic compounds that are fatty acids or their derivatives and are insoluble in water but soluble in organic solvents. They include many natural oils, waxes, and steroids.

SLNs are made up of solid lipid, emulsifier and water/solvent (Table 2). The lipids used may be triglycerides (tri-stearin), partial glycerides (Imwitor), fatty acids (stearic acid, palmitic acid), and steroids (cholesterol) and waxes (cetyl palmitate).

For nanoparticles in the size of 200 – 400 nm, the composition of the lipid matrix was shown to have an impact on the cytotoxicity of SLN (Schöler et al 2002). ... However, this also may be the major drawback for systemic administration of nanoparticles in terms of potential brain toxicity.

Solid Lipid Nanoparticles (SLN) SLNs represent a relatively new colloidal drug delivery system, composed of physiological lipids that remain in a solid state at both room and body temperature. These particles are in the size range of 50–1000 nm.19 Apr 2019