The Mac
@TheMac
19 February, 06:23
Optogenetics
is a technique whereby excitable cells,
such as neurons,
can be controlled at will
by light.
To do this,
cells are genetically engineered
to produce ion channels
called opsins
that sit in the cells'
membranes
and open
in response
to a certain wavelength of light.
is a technique whereby excitable cells,
such as neurons,
can be controlled at will
by light.
To do this,
cells are genetically engineered
to produce ion channels
called opsins
that sit in the cells'
membranes
and open
in response
to a certain wavelength of light.
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The Mac
@TheMac
19 February, 06:28
In response The Mac to his Publication
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The Mac
@TheMac
19 February, 06:29
In response The Mac to his Publication
In classic optogenetics, scientists implant optical fibers near opsin-dotted neurons to deliver the light stimulation. Computer-programmed light pulses can then target these newly light-sensitive neurons in a particular region of the brain and control their activity like puppets on a string.
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The Mac
@TheMac
19 February, 06:32
In response The Mac to his Publication
Despite efforts to visualize the spatio–temporal dynamics of single messenger RNAs, the ability to precisely control their function has lagged. This study presents an optogenetic approach for manipulating the localization and translation of specific mRNAs by trapping them in clusters.
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The Mac
@TheMac
19 February, 06:32
In response The Mac to his Publication
This clustering greatly amplified reporter signals, enabling endogenous RNA–protein interactions to be clearly visualized in single cells.
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The Mac
@TheMac
19 February, 06:33
In response The Mac to his Publication
Functionally, this sequestration reduced the ability of mRNAs to access ribosomes, markedly attenuating protein synthesis. A spatio–temporally resolved analysis indicated that sequestration of endogenous β-actin mRNA attenuated cell motility through the regulation of focal-adhesion dynamics.
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These results suggest a mechanism highlighting the indispensable role of newly synthesized β-actin protein for efficient cell migration. This platform may be broadly applicable for use in investigating the spatio–temporal activities of specific mRNAs in various biological processes.
06:33 PM - Feb 19, 2021
In response The Mac to his Publication
Only people mentioned by TheMac in this post can reply
The Mac
@TheMac
19 February, 06:35
In response The Mac to his Publication
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The Mac
@TheMac
19 February, 06:41
In response The Mac to his Publication
There has been an extensive body of research aimed at developing optogenetic tools to regulate gene expression. In a common strategy, a light-sensitive protecting group (‘photo-cage’) is chemically installed on a biologically relevant target (e.g. metabolites, oligonucleotides, or proteins) rendering the substrate inactive. Subsequently, light irradiation triggers the release of the ‘photo-cage’ from the target biological molecule, restoring its cellular activity.
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