A number of deoxyribonucleosides and their nucleoside analogs must be phosphorylated in order to be processed by deoxycytidine kinase (DCK). Resistance to antiviral and anticancer chemotherapy drugs is linked to DCK deficiency. Alternatively, elevated activation of these molecules to cytotoxic nucleoside triphosphate derivatives is linked to elevated deoxycytidine kinase activity. Due to its connection to both medication sensitivity and resistance, DCK is significant from a therapeutic standpoint.
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