Good evening. We will definitely be saying prayers for your wife. Both my husband and I suffer from sporadic charlie horses (leg cramps) in the night and they are horrible. We have a friend who is an ICU nurse and she said they use yellow mustard when a patient has a cramp. One packet does the trick. We just eat a big tablespoon and within minutes the cramp is gone. She and her colleagues do not know why it works, but it's important for a patient who cannot get out of bed. I highly recommend it. Doesn't taste the best, but the relief is miraculous. God bless.