The Mac @TheMac
08 June, 12:02
"Cooperation is ingrained in the DNA of the NHS"

-Matt Hancock

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The Mac @TheMac
08 June, 12:31
In response The Mac to his Publication
DNA is a dynamic and adaptable molecule.

As such, the nucleotide sequences found within it are subject to change as the result of a phenomenon called mutation.

Depending on how a particular mutation modifies an organism's genetic makeup, it can prove harmless, helpful, or even hurtful.

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The Mac @TheMac
08 June, 12:35
In response The Mac to his Publication
DNA-functionalization of quantum dots is the attachment of strands of DNA to the surface of a quantum dot. Although quantum dots with Cd have some cytotoxic release, researchers have functionalized quantum dots for biocompatibility and bound them to DNA in order to combine the advantages of both materials. Quantum dots are commonly used for imaging biological systems in vitro and in vivo in animal studies due to their excellent optical properties when excited by light, while DNA has numerous bioengineering applications, including: genetic engineering, self-assembling nanostructures, protein binding, and biomarkers. The ability to visualize the chemical and biological processes of DNA allows feedback to optimize and learn about these small scale behaviors.

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The Mac @TheMac
08 June, 12:36
In response The Mac to his Publication
Quantum dots are inorganic nanocrystal semiconductors that behave exceptionally well as fluorophores. In the field of biology, fluorophores are one of the few tools that allow us to peer inside of a live biological system at a cellular level. As a fluorophore, the size of a quantum dot directly reflects the wavelength of light emitted, allowing for a highly tunable color spectrum.

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The Mac @TheMac
08 June, 12:37
In response The Mac to his Publication
A spectrum disorder is a mental disorder that includes a range of linked conditions, sometimes also extending to include singular symptoms and traits. The different elements of a spectrum either have a similar appearance or are thought to be caused by the same underlying mechanism.

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The Mac @TheMac
Summary
Quantum dots (QDs) are luminescent nanoparticles with unique optical properties that have been exploited for single-cell and whole-animal imaging. When coated with proteins or biocompatible polymers, QDs are not deleterious to cells and organisms. However, when QDs are retained in cells or accumulated in the body for a long period of time, their coatings may be degraded, yielding “naked” QDs. Here, we show that “naked” QDs induce damage to the plasma membrane, mitochondrion, and nucleus, leading to cell death. Reactive oxygen species (ROS) are important players in mediating QD-induced cellular damage.
12:41 PM - Jun 08, 2021
In response The Mac to his Publication
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The Mac @TheMac
08 June, 12:44
In response The Mac to his Publication
According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites' surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparent morphological differences between children with ASD and typically developing children. ASD is diagnosed based upon a triad of features including impairment in socialization, impairment in language, and repetitive and stereotypic behaviors.

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The Mac @TheMac
08 June, 12:44
In response The Mac to his Publication
The increasing incidence of ASD in the pediatric population and the lack of successful curative therapies make ASD one of the most challenging disorders for medicine. ASD neurobiology is thought to be associated with oxidative stress, as shown by increased levels of reactive oxygen species and increased lipid peroxidation, as well as an increase in other indicators of oxidative stress. Children with ASD diagnosis are considered more vulnerable to oxidative stress because of their imbalance in intracellular and extracellular glutathione levels and decreased glutathione reserve capacity.

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